PMID- 21924686
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20120117
IS  - 1878-7533 (Electronic)
IS  - 1550-7289 (Linking)
VI  - 8
IP  - 1
DP  - 2012 Jan-Feb
TI  - Type 2 diabetes in obese patients with body mass index of 30-35 kg/m2: sleeve 
      gastrectomy versus medical treatment.
PG  - 20-4
LID - 10.1016/j.soard.2011.06.015 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) and obesity are diseases of epidemic 
      proportions. Long-term realistic weight loss by nonsurgical methods has a 
      variable effect on glycemic control, and only a proportion of patients with T2DM 
      have a worthwhile response. Laparoscopic sleeve gastrectomy (LSG) has been 
      proposed as an advantageous bariatric procedure for patients with a lower body 
      mass index (BMI). Our objective was to compare the effects of LSG and medical 
      therapy on patients with T2DM and a BMI of <35 kg/m(2). METHODS: A total of 18 
      nonmorbidly obese patients with T2DM, diagnosed according to the American 
      Diabetes Association guidelines, were consecutively enrolled. Of these patients, 
      9 underwent LSG (group A) and 9 underwent conventional medical therapy (group B). 
      The 2 groups were matched for BMI, glycated hemoglobin (HbA1c) and C-peptide 
      levels, pretrial therapy type, and number of patients with a T2DM duration of >10 
      years. RESULTS: In group A, T2DM resolution was achieved in 8 (88.8%) of the 9 
      patients (T2DM duration 5.2 yr). Hypertension was controlled in all 8 of 9 
      patients. Dyslipidemia was corrected. In 1 patient, obstructive sleep apnea 
      syndrome improved. In group B, all 9 patients continued to have T2DM and required 
      hypertensive and hypolipemic therapies throughout the observation period. At 
      baseline, 3 patients were affected by obstructive sleep apnea syndrome and 
      remained affected 1 year later. CONCLUSION: The results of the present study have 
      confirmed the efficacy of LSG in the treatment of nonmorbidly obese T2DM 
      patients, with a remission rate of 88.8% without undesirable excessive weight 
      loss. The results in this group of patients add to those obtained by us in 
      patients with a BMI >35 kg/m(2).
CI  - Copyright (c) 2012 American Society for Metabolic and Bariatric Surgery. Published 
      by Elsevier Inc. All rights reserved.
FAU - Abbatini, Francesca
AU  - Abbatini F
AD  - Surgical-Medical Department for Digestive Diseases, Policlinico Umberto I, 
      University La Sapienza, Rome, Italy.
FAU - Capoccia, Danila
AU  - Capoccia D
FAU - Casella, Giovanni
AU  - Casella G
FAU - Coccia, Federica
AU  - Coccia F
FAU - Leonetti, Frida
AU  - Leonetti F
FAU - Basso, Nicola
AU  - Basso N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110713
PL  - United States
TA  - Surg Obes Relat Dis
JT  - Surgery for obesity and related diseases : official journal of the American 
      Society for Bariatric Surgery
JID - 101233161
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - *Diabetes Mellitus, Type 2
MH  - Female
MH  - Gastrectomy/*methods
MH  - Humans
MH  - Laparoscopy/*methods
MH  - Male
MH  - Middle Aged
MH  - Obesity/*surgery
MH  - Treatment Outcome
EDAT- 2011/09/20 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/09/20 06:00
PHST- 2011/03/09 00:00 [received]
PHST- 2011/06/30 00:00 [accepted]
PHST- 2011/09/20 06:00 [entrez]
PHST- 2011/09/20 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - S1550-7289(11)00548-X [pii]
AID - 10.1016/j.soard.2011.06.015 [doi]
PST - ppublish
SO  - Surg Obes Relat Dis. 2012 Jan-Feb;8(1):20-4. doi: 10.1016/j.soard.2011.06.015. 
      Epub 2011 Jul 13.