PMID- 21924912
OWN - NLM
STAT- MEDLINE
DCOM- 20120210
LR  - 20221207
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 18
IP  - 11
DP  - 2011 Nov
TI  - Association between HLA-DRB1 and myasthenia gravis in a northern Han Chinese 
      population.
PG  - 1524-7
LID - 10.1016/j.jocn.2011.05.002 [doi]
AB  - The cause of myasthenia gravis (MG) is unknown, but it is widely believed to be 
      an autoimmune disease occurring in genetically susceptible individuals. The human 
      leukocyte antigen (HLA) region is considered to be the most important genetic 
      region for MG susceptibility genes. To investigate the association between 
      HLA-DRB1 and myasthenia gravis (MG) in a northern Han Chinese population, a 
      polymerase chain reaction with sequence-specific oligonucleotide probe 
      hybridization method was used to determine the HLA-DRB1 genotypes of 91 patients 
      with MG and 171 healthy individuals. We found that the HLA-DRB1(*)09 allele was 
      significantly more prevalent among patients with MG than among healthy controls, 
      especially those who experienced early onset of the disease (</=40 years), those 
      who were seronegative for acetylcholine receptor antibody, and those with ocular 
      MG. The prevalence of the HLA-DRB1(*)08 allele was significantly lower among 
      patients with MG than among controls. These results indicate that HLA-DRB1(*)09 
      might be positively associated and DRB1(*)08 negatively associated with MG in the 
      northern Han Chinese population.
CI  - Copyright (c) 2011. Published by Elsevier Ltd.
FAU - Xie, Yan-Chen
AU  - Xie YC
AD  - Department of Neurology, Beijing Friendship Hospital, Capital Medical University, 
      No. 95 Yong'an Rd., Xuanwu District, Beijing 100050, China.
FAU - Qu, Yuan
AU  - Qu Y
FAU - Sun, Liang
AU  - Sun L
FAU - Li, Hai-Feng
AU  - Li HF
FAU - Zhang, Hua
AU  - Zhang H
FAU - Shi, Hui-Jing
AU  - Shi HJ
FAU - Jiang, Bin
AU  - Jiang B
FAU - Zhao, Yuan
AU  - Zhao Y
FAU - Qiao, Shan-Shan
AU  - Qiao SS
FAU - Wang, Shu-Hui
AU  - Wang SH
FAU - Wang, De-Xin
AU  - Wang DX
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110915
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Alleles
MH  - Asian People/genetics
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myasthenia Gravis/*genetics
EDAT- 2011/09/20 06:00
MHDA- 2012/02/11 06:00
CRDT- 2011/09/20 06:00
PHST- 2010/11/02 00:00 [received]
PHST- 2011/04/11 00:00 [revised]
PHST- 2011/05/04 00:00 [accepted]
PHST- 2011/09/20 06:00 [entrez]
PHST- 2011/09/20 06:00 [pubmed]
PHST- 2012/02/11 06:00 [medline]
AID - S0967-5868(11)00297-9 [pii]
AID - 10.1016/j.jocn.2011.05.002 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2011 Nov;18(11):1524-7. doi: 10.1016/j.jocn.2011.05.002. Epub 
      2011 Sep 15.