PMID- 21924921
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20171116
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 56
IP  - 3
DP  - 2011 Dec
TI  - Systemic inflammation and cell activation reflects morbidity in chronic heart 
      failure.
PG  - 593-9
LID - 10.1016/j.cyto.2011.08.029 [doi]
AB  - Chronic heart failure (CHF) leads to complex effects distant from the heart. As 
      these changes may be reflected in the balance of systemic inflammatory and 
      fibrotic immunomodulators we measured these potential biomarkers in ambulatory 
      CHF patients. Using the New York Heart Association (NYHA; levels II-IV) 
      functional classification, 30 CHF patients were compared with 21 age and gender 
      matched controls. Peripheral blood levels of regulatory cytokines (TNF-alpha, TGF-beta, 
      KGF, IL-8, IL-10 and IL-12) and markers of cellular activation (CD11b, CD16, 
      CD18, CD34, HLADR, CXCR1 and CCR5) were analysed by ELISA and flow cytometry, 
      respectively. NYHA classification, which reflected increasing pulmonary 
      microvascular pressure (E:E') but not ejection fraction, was positively 
      associated with TGF-beta and IL-10 (p</=0.03). Similarly, monocytes, as well as cell 
      surface expression of the neutrophil adhesion molecule CD11b, and the macrophage 
      complement receptor complex (CD11b/CD18), were increased in CHF patients 
      (p</=0.03), while the chemokine receptor CXCR1 was decreased on cells of CHF 
      patients. Twenty month follow-up of CHF subjects identified monocyte number as a 
      powerful prognostic factor for cardio-pulmonary adverse events (p=0.001); 
      however, no concurrent relationship with cellular activation marker expression 
      was found. In subjects with CHF, monocytes, TGF-beta, IL-10, CD11b/CD18 and CXCR1 
      expression in peripheral blood may act as novel biomarkers of immune activation 
      and remodelling. Given the importance of dyspnea and the relationship of 
      pulmonary microvascular pressure to the NYHA classification, we suggest these 
      findings may reflect a contribution by the lung.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Dixon, Dani-Louise
AU  - Dixon DL
AD  - Intensive and Critical Care Unit, Flinders Medical Centre, Adelaide, Australia. 
      dani.dixon@flinders.edu.au
FAU - Griggs, Kim M
AU  - Griggs KM
FAU - Bersten, Andrew D
AU  - Bersten AD
FAU - De Pasquale, Carmine G
AU  - De Pasquale CG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110915
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Biomarkers)
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Cell Membrane/metabolism
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/blood/classification/*complications/*epidemiology
MH  - Humans
MH  - Inflammation/blood/*complications/immunology/*pathology
MH  - Kaplan-Meier Estimate
MH  - Leukocyte Common Antigens/metabolism
MH  - Leukocytes/pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Young Adult
EDAT- 2011/09/20 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/09/20 06:00
PHST- 2010/12/09 00:00 [received]
PHST- 2011/07/19 00:00 [revised]
PHST- 2011/08/19 00:00 [accepted]
PHST- 2011/09/20 06:00 [entrez]
PHST- 2011/09/20 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - S1043-4666(11)00708-3 [pii]
AID - 10.1016/j.cyto.2011.08.029 [doi]
PST - ppublish
SO  - Cytokine. 2011 Dec;56(3):593-9. doi: 10.1016/j.cyto.2011.08.029. Epub 2011 Sep 
      15.