PMID- 21925640
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20211020
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 153
IP  - 1
DP  - 2012 Jan
TI  - Subfoveal fluid in healthy full-term newborns observed by handheld 
      spectral-domain optical coherence tomography.
PG  - 167-75.e3
LID - 10.1016/j.ajo.2011.06.017 [doi]
AB  - PURPOSE: To report retinal findings for healthy newborn infants imaged with 
      handheld spectral-domain optical coherence tomography (SD OCT). DESIGN: 
      Prospective, observational case series. METHODS: Thirty-nine full-term newborn 
      infants underwent dilated retinal examinations by indirect ophthalmoscopy and 
      retinal imaging by handheld SD OCT, without sedation, at the Duke Birthing 
      Center. RESULTS: Of the 39 infants imaged, 44% (17/39) were male. Race and 
      ethnicity composition was 56% white, 38% black, 3% Asian, and 3% Hispanic. Median 
      gestational age was 39 weeks (range, 36 to 41 weeks). Six (15%) of the 39 infants 
      had bilateral subfoveal fluid on SD OCT not seen by indirect ophthalmoscopy. 
      Eight infants (21%) had retinal hemorrhages noted on dilated retinal examination, 
      1 of which had subretinal fluid on SD OCT. Subretinal fluid was noted on 
      follow-up examination to have resolved on SD OCT 1 to 4 months later. Infants 
      with bilateral subretinal fluid had an older gestational age compared with 
      infants without subretinal fluid (median, 40.4 vs 39.1 weeks, respectively; P = 
      .03) and were more likely to have had mothers with diabetes (2/6 vs 0/33, 
      respectively; P = .02). Vaginal versus Caesarian section delivery was not 
      significantly different between the 2 groups. CONCLUSIONS: Some healthy full-term 
      infants have bilateral subfoveal fluid not obvious on dilated retinal 
      examination. This fluid resolves within several months. The visual significance 
      of this finding is unknown, but clinicians should be aware that it is common when 
      evaluating newborn infants for retinal pathologic features using SD OCT.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Cabrera, Michelle T
AU  - Cabrera MT
AD  - Department of Ophthalmology, Duke Eye Center, Durham, North Carolina 27710, USA.
FAU - Maldonado, Ramiro S
AU  - Maldonado RS
FAU - Toth, Cynthia A
AU  - Toth CA
FAU - O'Connell, Rachelle V
AU  - O'Connell RV
FAU - Chen, Bei Bei
AU  - Chen BB
FAU - Chiu, Stephanie J
AU  - Chiu SJ
FAU - Farsiu, Sina
AU  - Farsiu S
FAU - Wallace, David K
AU  - Wallace DK
FAU - Stinnett, Sandra S
AU  - Stinnett SS
FAU - Panayotti, Gabriela M Maradiaga
AU  - Panayotti GM
FAU - Swamy, Geeta K
AU  - Swamy GK
FAU - Freedman, Sharon F
AU  - Freedman SF
LA  - eng
GR  - UL1 RR024128/RR/NCRR NIH HHS/United States
GR  - UL1 RR024128-01/RR/NCRR NIH HHS/United States
GR  - 1UL1 RR024128-01/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110916
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Birth Weight
MH  - Female
MH  - Fovea Centralis/*metabolism
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Ophthalmology/instrumentation
MH  - Ophthalmoscopy
MH  - Prospective Studies
MH  - Retinal Hemorrhage/diagnosis
MH  - Subretinal Fluid/*metabolism
MH  - Term Birth/*physiology
MH  - *Tomography, Optical Coherence
PMC - PMC3496561
MID - NIHMS309298
EDAT- 2011/09/20 06:00
MHDA- 2012/02/02 06:00
PMCR- 2013/01/01
CRDT- 2011/09/20 06:00
PHST- 2011/03/25 00:00 [received]
PHST- 2011/06/13 00:00 [revised]
PHST- 2011/06/14 00:00 [accepted]
PHST- 2011/09/20 06:00 [entrez]
PHST- 2011/09/20 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - S0002-9394(11)00515-0 [pii]
AID - 10.1016/j.ajo.2011.06.017 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2012 Jan;153(1):167-75.e3. doi: 10.1016/j.ajo.2011.06.017. Epub 
      2011 Sep 16.