PMID- 21925737 OWN - NLM STAT- MEDLINE DCOM- 20120126 LR - 20240214 IS - 1549-4713 (Electronic) IS - 0161-6420 (Print) IS - 0161-6420 (Linking) VI - 118 IP - 12 DP - 2011 Dec TI - Complications, adverse events, and additional intraocular surgery 1 year after cataract surgery in the infant Aphakia Treatment Study. PG - 2330-4 LID - 10.1016/j.ophtha.2011.06.017 [doi] AB - PURPOSE: To compare rates and severity of complications between infants undergoing cataract surgery with and without intraocular lens (IOL) implantation. DESIGN: Prospective, randomized clinical trial. PARTICIPANTS: The Infant Aphakia Treatment Study (IATS) is a randomized, multicenter (n = 12) clinical trial comparing treatment of aphakia with a primary IOL or contact lens in 114 infants with unilateral congenital cataract. INTERVENTION: Infants underwent cataract surgery with or without placement of an IOL. MAIN OUTCOME MEASURES: The rate, character, and severity of intraoperative complications (ICs), adverse events (AEs), and additional intraocular surgeries (AISs) during the first postoperative year in the 2 groups were analyzed. RESULTS: There were more patients with ICs (28% vs. 11%; P = 0.031), AEs (77% vs. 25%; P<0.0001), and AISs (63% vs. 12%; P<0.0001) in the IOL group than the contact lens group. Iris prolapse was the most common IC. The most common AE was visual axis opacification, and the most common additional intraocular reoperation was a clearing of visual axis opacification. CONCLUSIONS: The rates of ICs, AEs, and AISs 1 year after surgery were numerically higher in the IOL group, but their functional impact does not clearly favor either treatment group. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article. CI - Copyright (c) 2011 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved. FAU - Plager, David A AU - Plager DA AD - Indiana University Medical Center, Indianapolis, Indiana 46202, USA. dplager@iupui.edu FAU - Lynn, Michael J AU - Lynn MJ FAU - Buckley, Edward G AU - Buckley EG FAU - Wilson, M Edward AU - Wilson ME FAU - Lambert, Scott R AU - Lambert SR CN - Infant Aphakia Treatment Study Group LA - eng GR - U10 EY13272/EY/NEI NIH HHS/United States GR - U10 EY013272/EY/NEI NIH HHS/United States GR - R21 EY011987-01A1/EY/NEI NIH HHS/United States GR - U10 EY013272-01A2/EY/NEI NIH HHS/United States GR - U10 EY013287/EY/NEI NIH HHS/United States GR - UG1 EY025553/EY/NEI NIH HHS/United States GR - P30 EY006360/EY/NEI NIH HHS/United States GR - R21 ES011987/ES/NIEHS NIH HHS/United States GR - EY06360/EY/NEI NIH HHS/United States PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20110916 PL - United States TA - Ophthalmology JT - Ophthalmology JID - 7802443 SB - IM CIN - Ophthalmology. 2012 Jul;119(7):1503-4;author reply 1504-5. PMID: 22749102 MH - Aphakia, Postcataract/physiopathology/*therapy MH - Capsule Opacification/etiology/surgery MH - Cataract/*congenital MH - *Cataract Extraction MH - *Contact Lenses MH - Humans MH - Infant MH - Infant, Newborn MH - *Intraoperative Complications MH - *Lens Implantation, Intraocular MH - *Postoperative Complications MH - Prospective Studies MH - Reoperation MH - Visual Acuity/physiology PMC - PMC3230731 MID - NIHMS308887 COIS- No conflicting relationship exists for any author. FIR - Lambert, Scott R IR - Lambert SR FIR - DuBois, Lindreth IR - DuBois L FIR - Lynn, Michael IR - Lynn M FIR - Bridgman, Betsy IR - Bridgman B FIR - Celano, Marianne IR - Celano M FIR - Cleveland, Julia IR - Cleveland J FIR - Cotsonis, George IR - Cotsonis G FIR - Drews-Botsch, Carey IR - Drews-Botsch C FIR - Freret, Nana IR - Freret N FIR - Lu, Lu IR - Lu L FIR - Nizam, Azhar IR - Nizam A FIR - Swanson, Seegar IR - Swanson S FIR - Tutu, Thandeka IR - Tutu T FIR - Hartmann, E Eugenie IR - Hartmann EE FIR - Edwards, Clara IR - Edwards C FIR - Busettini, Claudio IR - Busettini C FIR - Hayley, Samuel IR - Hayley S FIR - Lambert, Scott R IR - Lambert SR FIR - Buckley, Edward G IR - Buckley EG FIR - Plager, David A IR - Plager DA FIR - Wilson, M Edward IR - Wilson ME FIR - Lynn, Michael IR - Lynn M FIR - DuBois, Lindreth IR - DuBois L FIR - Drews-Botsch, Carolyn IR - Drews-Botsch C FIR - Hartmann, E Eugenie IR - Hartmann EE FIR - Everett, Donald F IR - Everett DF FIR - Russell, Buddy IR - Russell B FIR - Ward, Michael IR - Ward M FIR - Wilson, M Edward IR - Wilson ME FIR - Bozic, Margaret IR - Bozic M FIR - VanderVeen, Deborah K IR - VanderVeen DK FIR - Mansfield, Theresa A IR - Mansfield TA FIR - Miller, Kathryn Bisceglia IR - Miller KB FIR - Christiansen, Stephen P IR - Christiansen SP FIR - Bothun, Erick D IR - Bothun ED FIR - Holleschau, Ann IR - Holleschau A FIR - Jedlicka, Jason IR - Jedlicka J FIR - Winters, Patricia IR - Winters P FIR - Lang, Jacob IR - Lang J FIR - Traboulsi, Elias I IR - Traboulsi EI FIR - Crowe, Susan IR - Crowe S FIR - Cimino, Heather Hasley IR - Cimino HH FIR - Yen, Kimberly G IR - Yen KG FIR - Castanes, Maria IR - Castanes M FIR - Sanchez, Alma IR - Sanchez A FIR - York, Shirley IR - York S FIR - Wheeler, David T IR - Wheeler DT FIR - Stout, Ann U IR - Stout AU FIR - Rauch, Paula IR - Rauch P FIR - Beaudet, Kimberly IR - Beaudet K FIR - Berg, Pam IR - Berg P FIR - Lambert, Scott R IR - Lambert SR FIR - Hutchinson, Amy K IR - Hutchinson AK FIR - DuBois, Lindreth IR - DuBois L FIR - Robb, Rachel IR - Robb R FIR - Shainberg, Marla J IR - Shainberg MJ FIR - Buckley, Edward G IR - Buckley EG FIR - Freedman, Sharon F IR - Freedman SF FIR - Duncan, Lois IR - Duncan L FIR - Phillips, B W IR - Phillips BW FIR - Petrowski, John T IR - Petrowski JT FIR - Morrison, David IR - Morrison D FIR - Owings, Sandy IR - Owings S FIR - Biernacki, Ron IR - Biernacki R FIR - Franklin, Christine IR - Franklin C FIR - Plager, David A IR - Plager DA FIR - Neely, Daniel E IR - Neely DE FIR - Whitaker, Michele IR - Whitaker M FIR - Bates, Donna IR - Bates D FIR - Donaldson, Dana IR - Donaldson D FIR - Kruger, Stacey IR - Kruger S FIR - Tibi, Charlotte IR - Tibi C FIR - Vega, Susan IR - Vega S FIR - Weakley, David R IR - Weakley DR FIR - Stager, David R Jr IR - Stager DR Jr FIR - Felius, Joost IR - Felius J FIR - Dias, Clare IR - Dias C FIR - Sager, Debra L IR - Sager DL FIR - Brantley, Todd IR - Brantley T FIR - Hardy, Robert IR - Hardy R FIR - Birch, Eileen IR - Birch E FIR - Cheng, Ken IR - Cheng K FIR - Hertle, Richard IR - Hertle R FIR - Kollman, Craig IR - Kollman C FIR - Yeargin- Allsopp, Marshalyn IR - Yeargin- Allsopp M FIR - McDowell, Cyd IR - McDowell C FIR - Everett, Donald F IR - Everett DF FIR - Beck, Allen IR - Beck A EDAT- 2011/09/20 06:00 MHDA- 2012/01/27 06:00 PMCR- 2012/12/01 CRDT- 2011/09/20 06:00 PHST- 2011/03/25 00:00 [received] PHST- 2011/06/13 00:00 [revised] PHST- 2011/06/15 00:00 [accepted] PHST- 2011/09/20 06:00 [entrez] PHST- 2011/09/20 06:00 [pubmed] PHST- 2012/01/27 06:00 [medline] PHST- 2012/12/01 00:00 [pmc-release] AID - S0161-6420(11)00560-4 [pii] AID - 10.1016/j.ophtha.2011.06.017 [doi] PST - ppublish SO - Ophthalmology. 2011 Dec;118(12):2330-4. doi: 10.1016/j.ophtha.2011.06.017. Epub 2011 Sep 16.