PMID- 21926939
OWN - NLM
STAT- MEDLINE
DCOM- 20120508
LR  - 20151119
IS  - 1539-2864 (Electronic)
IS  - 0275-004X (Linking)
VI  - 32
IP  - 3
DP  - 2012 Mar
TI  - Longitudinal anatomical response of retinal-choroidal anastomosis to 
      anti-vascular endothelial growth factor therapy.
PG  - 458-67
LID - 10.1097/IAE.0b013e3182205960 [doi]
AB  - PURPOSE: To evaluate the longitudinal anatomical response of retinal-choroidal 
      anastomosis (RCA) to intravitreal ranibizumab injection using spectral-domain 
      optical coherence tomography (SD-OCT). METHODS: We reviewed the medical records 
      of 21 consecutive patients with RCA who underwent intravitreal ranibizumab 
      injections at the University Eye Clinic of Creteil between January 2009 and June 
      2010. The SD-OCT features at baseline, at 3 months, and at 12 months were 
      retrospectively analyzed. Based on SD-OCT, RCAs were classified as showing a 
      focal retinal pigment epithelium (RPE) erosion ("erosion sign") over a small, 
      localized RPE elevation; a focal RPE break leaving two free RPE flaps ("flap 
      sign") at the level of a small, localized RPE elevation; or a large convex RPE 
      prominence and a focal funnel-shaped RPE kissing an inverted focal funnel-shaped 
      inner neuroepithelium ("kissing sign"). RESULTS: Twenty-one eyes of 21 patients 
      (3 men and 18 women, aged 81.6 +/- 6.8 years) diagnosed with RCA naive to any 
      treatment were included for analysis. Spearman rho correlation between 
      best-corrected visual acuity and lesion classification was 0.54 (P = 0.01) at 
      Month 3 and 0.85 (P < 0.001) at Month 12. Eyes showing the flap sign at baseline 
      underwent significantly less ranibizumab injections after the loading phase (2.14 
      +/- 0.89 vs. 3.40 +/- 0.96, P = 0.007) and showed a greater improvement in 
      best-corrected visual acuity at Month 12 (from 0.52 +/- 0.14 to 0.38 +/- 0.15, P = 
      0.03) compared with eyes showing the kissing sign. At 12 months, 3 of 10 eyes 
      with flap sign at baseline showed RCA activity, whereas 7 of 10 regressed to 
      erosion sign phase. Of the 10 eyes with kissing sign at baseline, 6 progressed to 
      a fibroglial scar. CONCLUSION: A flap sign of RCA at baseline seems a favorable 
      prognostic factor as concerns best-corrected visual acuity improvement and the 
      need for retreatment.
FAU - Querques, Giuseppe
AU  - Querques G
AD  - Department of Ophthalmology, University of Paris XII, Centre Hospitalier 
      Intercommunal de Creteil, Creteil, France. giuseppe.querques@hotmail.it
FAU - Rousseau, Antoine
AU  - Rousseau A
FAU - Forte, Raimondo
AU  - Forte R
FAU - Scemama, Claire
AU  - Scemama C
FAU - Caillaux, Violane
AU  - Caillaux V
FAU - Querques, Lea
AU  - Querques L
FAU - Souied, Eric H
AU  - Souied EH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Retina
JT  - Retina (Philadelphia, Pa.)
JID - 8309919
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - ZL1R02VT79 (Ranibizumab)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiogenesis Inhibitors/*therapeutic use
MH  - Antibodies, Monoclonal, Humanized/*therapeutic use
MH  - Arteriovenous Anastomosis/*drug effects
MH  - Choroid/*blood supply
MH  - Female
MH  - Humans
MH  - Intravitreal Injections
MH  - Longitudinal Studies
MH  - Macular Degeneration/*drug therapy
MH  - Male
MH  - Prognosis
MH  - Ranibizumab
MH  - Retinal Vessels/*drug effects
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Vascular Endothelial Growth Factor A/*antagonists & inhibitors
MH  - Visual Acuity/physiology
EDAT- 2011/09/20 06:00
MHDA- 2012/05/09 06:00
CRDT- 2011/09/20 06:00
PHST- 2011/09/20 06:00 [entrez]
PHST- 2011/09/20 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
AID - 10.1097/IAE.0b013e3182205960 [doi]
PST - ppublish
SO  - Retina. 2012 Mar;32(3):458-67. doi: 10.1097/IAE.0b013e3182205960.