PMID- 21927904
OWN - NLM
STAT- MEDLINE
DCOM- 20130220
LR  - 20211020
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 32
IP  - 10
DP  - 2012 Oct
TI  - HLA-B27 subtypes in Turkish patients with ankylosing spondylitis and healthy 
      controls.
PG  - 3103-5
AB  - The aim of this study was to determine human leukocyte antigen (HLA)-B27 subtypes 
      frequency in ankylosing spondylitis (AS) and related spondyloartropathy (SpA) 
      patients. Therefore, we investigated the differences in HLA-B27 subtypes between 
      HLA-B27-positive patients and controls. Sixty six patients were included in this 
      study (51 AS and 15 SpA). Thirty-five individuals were diagnosed with leukemia or 
      chronic renal failure, and their donors without any rheumatological problem (no 
      SpA history) were selected as the control group. HLA-B27 subtyping was performed 
      by PCR-SSP (polymerase chain reaction with sequence-specific primer) method in 
      serologically HLA-B27-positive 46 AS patients, 9 SpA patients and control group. 
      When the frequency of HLA-B27 was 4.5% in Turkish population, this frequency was 
      90.2% in AS patients. Four different HLA-B27 subtypes found in AS patients were B 
      2705 (65.2%), B 2702 (26.1%), B 2704 (6.5%) and B 2707 (2.2%). In SpA patients, B 
      2705 and B 2702 found in equal frequency. Five B27 alleles were identified in our 
      control group: B 2705 (54.3%), B 2702 (31.4) %, B 2703 (2.9%), B 2704 (2.9%) and 
      B 2702/B 2705 (8.5%). Both in the patient group and in the control group, we also 
      observed B 2705 as most frequent allele, and B 2702 was second common allele. Our 
      results show that the frequency of HLA-B27 subtypes is not significantly 
      different between patients and controls (P > 0.10).
FAU - Acar, Muradiye
AU  - Acar M
AD  - Department of Genetics, Selcuk University Medical School, Konya, Turkey. 
      acarmuradiye@hotmail.com
FAU - Cora, Tulin
AU  - Cora T
FAU - Tunc, Recep
AU  - Tunc R
FAU - Acar, Hasan
AU  - Acar H
LA  - eng
PT  - Journal Article
DEP - 20110917
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (HLA-B*27:04 antigen)
RN  - 0 (HLA-B*27:05 antigen)
RN  - 0 (HLA-B*27:07 antigen)
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Case-Control Studies
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-B27 Antigen/*genetics
MH  - Humans
MH  - Phenotype
MH  - Polymerase Chain Reaction
MH  - Spondylitis, Ankylosing/*genetics/immunology
MH  - Turkey
EDAT- 2011/09/20 06:00
MHDA- 2013/02/21 06:00
CRDT- 2011/09/20 06:00
PHST- 2011/03/23 00:00 [received]
PHST- 2011/08/21 00:00 [accepted]
PHST- 2011/09/20 06:00 [entrez]
PHST- 2011/09/20 06:00 [pubmed]
PHST- 2013/02/21 06:00 [medline]
AID - 10.1007/s00296-011-2099-0 [doi]
PST - ppublish
SO  - Rheumatol Int. 2012 Oct;32(10):3103-5. doi: 10.1007/s00296-011-2099-0. Epub 2011 
      Sep 17.