PMID- 21929573
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20110920
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 78
IP  - 4
DP  - 2011 Oct
TI  - Frequency of HLA-A, -B and -DRB1 specificities and haplotypic associations in the 
      population of Castilla y Leon (northwest-central Spain).
PG  - 249-55
LID - 10.1111/j.1399-0039.2011.01766.x [doi]
AB  - The frequencies of human leukocyte antigen (HLA) class I and class II 
      specificities and haplotypic associations were determined in 1940 unrelated 
      donors from Castilla y Leon and compared with other Iberian, Mediterranean and 
      European populations. Specificities were determined using polymerase chain 
      reaction reverse sequence-specific oligonucleotide or polymerase chain reaction 
      sequence-specific primer techniques. In the analysis, 19, 29 and 13 specificities 
      were found for HLA-A, -B and -DRB1, respectively, with HLA-A*02 (26%), -A*01 
      (11%), -B*44 (16%), -B*35 (10%), -DRB1*07 (16%) and -DRB1*13 (14%) showing the 
      highest frequencies. In addition, 10 common HLA-A-B-DRB1 haplotypic associations 
      were observed, A*01-B*08-DRB1*03 (3%) and A*29-B*44-DRB1*07 (3%) being the most 
      frequent ones. These findings indicate that the population of Castilla y Leon is 
      genetically equidistant from the Portuguese and other Spanish populations and 
      shares a common origin with other Iberian populations, in which European, 
      Mediterranean and North African genetic components are present; this is in 
      agreement with the historical and genetic background of the population. These 
      data contribute to a better understanding of the genetic structure of the Iberian 
      Peninsula and provide a healthy control population from our region that should be 
      useful for the study of disease associations.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Alcoceba, M
AU  - Alcoceba M
AD  - Laboratorio de Biologia Molecular/HLA, Servicio de Hematologia, Hospital 
      Universitario de Salamanca, Salamanca, Spain.
FAU - Marin, L
AU  - Marin L
FAU - Balanzategui, A
AU  - Balanzategui A
FAU - Sarasquete, M E
AU  - Sarasquete ME
FAU - Chillon, M C
AU  - Chillon MC
FAU - Martin-Jimenez, P
AU  - Martin-Jimenez P
FAU - Puig, N
AU  - Puig N
FAU - Santamaria, C
AU  - Santamaria C
FAU - Corral, R
AU  - Corral R
FAU - Garcia-Sanz, R
AU  - Garcia-Sanz R
FAU - San Miguel, J F
AU  - San Miguel JF
FAU - Gonzalez, M
AU  - Gonzalez M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Female
MH  - *Gene Frequency
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - *Haplotypes
MH  - Humans
MH  - Male
MH  - Spain/ethnology
EDAT- 2011/09/21 06:00
MHDA- 2012/01/13 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
AID - 10.1111/j.1399-0039.2011.01766.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2011 Oct;78(4):249-55. doi: 10.1111/j.1399-0039.2011.01766.x.