PMID- 21930126
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20220408
IS  - 1096-0945 (Electronic)
IS  - 0014-4800 (Linking)
VI  - 91
IP  - 3
DP  - 2011 Dec
TI  - Protective effects of Ginkgo biloba (EGb 761) on testicular 
      torsion/detorsion-induced ischemia-reperfusion injury in rats.
PG  - 708-13
LID - 10.1016/j.yexmp.2011.09.003 [doi]
AB  - The aim of this study was to investigate the protective effect of Ginkgo biloba 
      (EGb 761) on testicular torsion/detorsion induced ischemia-reperfusion (I/R) 
      injury. A total of 24 male Wistar albino rats were divided into three groups: 
      control, I/R and I/R treated with EGb 761; each group contains 8 animals. 
      Testicular torsion was created by rotating the left testis 720 degrees  in a clockwise 
      direction. The ischemia period was 5 h and orchiectomy was performed after 5 h of 
      detorsion. EGb 761 (50 mg/kg, orally) was administrated only once, 40 min prior 
      to detorsion. To date, no more histopathological changes on testicular 
      torsion/detorsion induced ischemia-reperfusion (I/R) injury in rats by EGb 761 
      treatment have been reported. Spermatogenesis and mean seminiferous tubule 
      diameter (MSTD) were significantly decreased in I/R groups were compared to the 
      control group. Furthermore, EGb 761 treated animals showed an improved 
      histological appearance in I/R group. Our data indicate a significant reduction 
      in the activity of TUNEL and endothelial nitric oxide synthase (eNOS) in testes 
      tissue of I/R treated with EGb 761 therapy. Electron microscopy of the testes of 
      rats demonstrated that EGb 761 pretreatment was particularly effective in 
      preventing the mitochondrial degeneration, dilatation of SER and enlarged 
      intercellular spaces in both Sertoli and spermatid cells in I/R treated animals. 
      We believe that further preclinical research into the utility of EGb 761 may 
      indicate its usefulness as a potential treatment on testes injury after I/R in 
      rats.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Kanter, Mehmet
AU  - Kanter M
AD  - Department of Histology and Embryology, Faculty of Medicine, University of 
      Trakya, Edirne, Turkey. mkanter65@yahoo.com
LA  - eng
PT  - Journal Article
DEP - 20110909
PL  - Netherlands
TA  - Exp Mol Pathol
JT  - Experimental and molecular pathology
JID - 0370711
RN  - 0 (Plant Extracts)
RN  - 19FUJ2C58T (Ginkgo biloba extract)
RN  - EC 1.14.13.39 (NOS3 protein, human)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type III)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - *Ginkgo biloba
MH  - In Situ Nick-End Labeling
MH  - Male
MH  - Nitric Oxide Synthase Type III/metabolism
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Reperfusion Injury/etiology/metabolism/pathology/*prevention & control
MH  - Spermatic Cord Torsion/*complications/metabolism/pathology
MH  - Spermatogenesis
MH  - Testis/metabolism/pathology
EDAT- 2011/09/21 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/04/19 00:00 [received]
PHST- 2011/07/03 00:00 [revised]
PHST- 2011/09/02 00:00 [accepted]
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - S0014-4800(11)00137-7 [pii]
AID - 10.1016/j.yexmp.2011.09.003 [doi]
PST - ppublish
SO  - Exp Mol Pathol. 2011 Dec;91(3):708-13. doi: 10.1016/j.yexmp.2011.09.003. Epub 
      2011 Sep 9.