PMID- 21930272
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20161125
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 219
IP  - 2
DP  - 2011 Dec
TI  - Qualitative score of systemic arteriosclerosis by vascular ultrasonography as a 
      predictor of coronary artery disease in type 2 diabetes.
PG  - 623-9
LID - 10.1016/j.atherosclerosis.2011.08.043 [doi]
AB  - OBJECTIVE: Patients with type 2 diabetes mellitus (T2DM) are at risk of 
      polyvascular comorbidities and poor prognosis. Non-invasive techniques for early 
      prediction of coronary artery disease (CAD) are desirable to prevent 
      cardiovascular events in these patients. The aim of the present study was to 
      investigate the association between CAD and systemic arteriosclerosis by 
      qualitative vascular ultrasonography. METHODS: The study subjects were 102 
      consecutive outpatients with T2DM [males/females = 60/42, age: mean +/- SD 67 +/- 9 
      (range, 40-85) years] evaluated by vascular ultrasonography for arteriosclerosis 
      in the abdominal aorta, carotid, renal, and common iliac arteries. The total 
      number of detected arteriosclerotic vascular lesions in the four arteries was 
      determined. CAD was diagnosed by two cardiologists using either stress 
      electrocardiography, myocardial scintigraphy, multi-detector row computed 
      tomography or coronary angiography. RESULTS: Multiple arteriosclerotic vascular 
      lesions (>1) were detected in 64 (63%) patients. The total systemic vascular 
      score was significantly higher in patients with CAD than those without (average 
      score 2.7 versus 1.0, p < 0.0001). None of the CAD patients had a total score of 
      0. Age- and sex-adjusted multiple logistic regression analysis identified total 
      score of >/= 2 as the only predictor of CAD (p < 0.001). The sensitivity, 
      specificity, positive and negative predictive values for total systemic vascular 
      score in the prediction of CAD were 98%, 77%, 83%, and 97%, respectively, which 
      were better than those for carotid mean and maximum intima-media thickness. 
      CONCLUSION: Non-invasive qualitative evaluation of systemic arteriosclerosis by 
      the total systemic vascular score is potentially useful for the early prediction 
      of CAD in T2DM patients.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Hirata, Ayumu
AU  - Hirata A
AD  - Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 
      Osaka, Japan.
FAU - Kishida, Ken
AU  - Kishida K
FAU - Hiuge-Shimizu, Aki
AU  - Hiuge-Shimizu A
FAU - Nakatsuji, Hideaki
AU  - Nakatsuji H
FAU - Funahashi, Tohru
AU  - Funahashi T
FAU - Shimomura, Iichiro
AU  - Shimomura I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110903
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aorta, Abdominal/*diagnostic imaging
MH  - Arteriosclerosis/*diagnostic imaging/etiology
MH  - Carotid Arteries/*diagnostic imaging
MH  - Chi-Square Distribution
MH  - Coronary Angiography/methods
MH  - Coronary Artery Disease/*diagnosis/diagnostic imaging/etiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Angiopathies/*diagnostic imaging/etiology
MH  - Early Diagnosis
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Iliac Artery/*diagnostic imaging
MH  - Japan
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Myocardial Perfusion Imaging
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Renal Artery/*diagnostic imaging
MH  - Risk Assessment
MH  - Risk Factors
MH  - Tomography, X-Ray Computed
MH  - *Ultrasonography, Interventional
EDAT- 2011/09/21 06:00
MHDA- 2012/04/06 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/06/15 00:00 [received]
PHST- 2011/08/22 00:00 [revised]
PHST- 2011/08/25 00:00 [accepted]
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
AID - S0021-9150(11)00847-1 [pii]
AID - 10.1016/j.atherosclerosis.2011.08.043 [doi]
PST - ppublish
SO  - Atherosclerosis. 2011 Dec;219(2):623-9. doi: 
      10.1016/j.atherosclerosis.2011.08.043. Epub 2011 Sep 3.