PMID- 21931317
OWN - NLM
STAT- MEDLINE
DCOM- 20120508
LR  - 20211020
IS  - 1476-5578 (Electronic)
IS  - 1359-4184 (Print)
IS  - 1359-4184 (Linking)
VI  - 17
IP  - 1
DP  - 2012 Jan
TI  - BDNF function as a potential mediator of bipolar disorder and post-traumatic 
      stress disorder comorbidity.
PG  - 22-35
LID - 10.1038/mp.2011.121 [doi]
AB  - Bipolar disorder (BD) and post-traumatic stress disorder (PTSD) frequently 
      co-occur among psychiatric patients, leading to increased morbidity and 
      mortality. Brain-derived neurotrophic factor (BDNF) function is associated with 
      core characteristics of both BD and PTSD. We propose a neurobiological model that 
      underscores the role of reduced BDNF function resulting from several contributing 
      sources, including the met variant of the BDNF val66met (rs6265) 
      single-nucleotide polymorphism, trauma-induced epigenetic regulation and current 
      stress, as a contributor to the onset of both illnesses within the same person. 
      Further studies are needed to evaluate the genetic association between the 
      val66met allele and the BD-PTSD population, along with central/peripheral BDNF 
      levels and epigenetic patterns of BDNF gene regulation within these patients.
FAU - Rakofsky, J J
AU  - Rakofsky JJ
AD  - Mood and Anxiety Disorders Program/Bipolar Disorders Clinic, Emory University 
      Department of Psychiatry and Behavioral Sciences, Atlanta, GA 30306, USA. 
      Jrakofs@emory.edu
FAU - Ressler, K J
AU  - Ressler KJ
FAU - Dunlop, B W
AU  - Dunlop BW
LA  - eng
GR  - K23 MH086690/MH/NIMH NIH HHS/United States
GR  - UL1 RR025008/RR/NCRR NIH HHS/United States
GR  - UL1 TR000454/TR/NCATS NIH HHS/United States
GR  - K23MH086690/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20110920
PL  - England
TA  - Mol Psychiatry
JT  - Molecular psychiatry
JID - 9607835
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Bipolar Disorder/*epidemiology/genetics/*metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Comorbidity
MH  - Humans
MH  - Methionine/genetics
MH  - Stress Disorders, Post-Traumatic/*epidemiology/genetics/*metabolism
MH  - Valine/genetics
PMC - PMC3690922
MID - NIHMS471207
COIS- Conflict of interest The authors declare no conflict of interest.
EDAT- 2011/09/21 06:00
MHDA- 2012/05/09 06:00
PMCR- 2013/06/24
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
PHST- 2013/06/24 00:00 [pmc-release]
AID - mp2011121 [pii]
AID - 10.1038/mp.2011.121 [doi]
PST - ppublish
SO  - Mol Psychiatry. 2012 Jan;17(1):22-35. doi: 10.1038/mp.2011.121. Epub 2011 Sep 20.