PMID- 21932132
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20211020
IS  - 1937-5395 (Electronic)
IS  - 1937-5387 (Linking)
VI  - 5
IP  - 3
DP  - 2012 Jun
TI  - Effects of continuous flow left ventricular assist device support on 
      microvascular endothelial function.
PG  - 345-50
LID - 10.1007/s12265-011-9321-z [doi]
AB  - The effects of continuous flow left ventricular assist device (CF-LVAD) support 
      on microvascular endothelial function in New York Heart Association (NYHA) class 
      IV heart failure (HF) patients are currently unknown. Microvascular endothelial 
      function was assessed by beat-to-beat plethysmographic measurement of finger 
      arterial pulse wave signal changes for 5 min following reactive hyperemia. A 
      group of seven NYHA class IV HF patients was evaluated before CF-LVAD placement 
      (HF), and a second group of six NYHA class IV HF patients was evaluated 1-4 
      months following CF-LVAD placement (CF-LVAD). Additionally, a third group of 
      seven age-matched healthy subjects served as controls (control). There was no 
      significant (P > 0.05) difference among the three groups in age, weight, or 
      height. Systolic blood pressure (BP) was significantly higher in the control 
      group (120 +/- 2 mmHg) as compared to that in the HF (97 +/- 8 mmHg, P = 0.005) and 
      CF-LVAD (106 +/- 4 mmHg, P = 0.003) groups. Diastolic BP was significantly lower in 
      the HF group (57 +/- 5 mmHg) as compared to that in the control (71 +/- 2 mmHg, P = 
      0.012) and CF-LVAD (80 +/- 7 mmHg, P = 0.008) groups. The reactive hyperemic index 
      (RHI), a measure of endothelial function, was significantly higher in the control 
      group (2.373 +/- 0.274) than in both the HF (1.543 +/- 0.173, P = 0.013) and CF-LVAD 
      (1.355 +/- 0.163, P = 0.004) groups; however, there was no significant (P = 0.223) 
      difference in RHI between the HF and CF-LVAD groups. The results of the present 
      study demonstrate that while 1-4 months of CF-LVAD support do not negatively 
      affect microvascular endothelial function, 1-4 months of CF-LVAD support do not 
      significantly improve vascular function in resistance vessels.
FAU - Lou, Xiaoying
AU  - Lou X
AD  - College of Biological Sciences, University of Minnesota, Minneapolis, MN, USA.
FAU - Templeton, Danielle L
AU  - Templeton DL
FAU - John, Ranjit
AU  - John R
FAU - Dengel, Donald R
AU  - Dengel DR
LA  - eng
PT  - Journal Article
DEP - 20110920
PL  - United States
TA  - J Cardiovasc Transl Res
JT  - Journal of cardiovascular translational research
JID - 101468585
SB  - IM
MH  - Blood Pressure
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Cross-Sectional Studies
MH  - Endothelium, Vascular/*physiopathology
MH  - Female
MH  - Fingers/*blood supply
MH  - Heart Failure/physiopathology/*therapy
MH  - *Heart-Assist Devices
MH  - Humans
MH  - Hyperemia/physiopathology
MH  - Male
MH  - *Microcirculation
MH  - Microvessels/*physiopathology
MH  - Middle Aged
MH  - Minnesota
MH  - Plethysmography
MH  - Prospective Studies
MH  - Prosthesis Design
MH  - Treatment Outcome
MH  - Vascular Resistance
MH  - *Ventricular Function, Left
EDAT- 2011/09/21 06:00
MHDA- 2012/09/11 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/06/09 00:00 [received]
PHST- 2011/09/09 00:00 [accepted]
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - 10.1007/s12265-011-9321-z [doi]
PST - ppublish
SO  - J Cardiovasc Transl Res. 2012 Jun;5(3):345-50. doi: 10.1007/s12265-011-9321-z. 
      Epub 2011 Sep 20.