PMID- 21932846
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20211020
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Print)
IS  - 0021-8561 (Linking)
VI  - 59
IP  - 21
DP  - 2011 Nov 9
TI  - Effects of green tea polyphenol (-)-epigallocatechin-3-gallate on newly developed 
      high-fat/Western-style diet-induced obesity and metabolic syndrome in mice.
PG  - 11862-71
LID - 10.1021/jf2029016 [doi]
AB  - The aim of this study was to investigate the effects of 
      (-)-epigallocatechin-3-gallate (EGCG) on newly developed high-fat/Western-style 
      diet-induced obesity and symptoms of metabolic syndrome. Male C57BL/6J mice were 
      fed a high fat/Western-style (HFW; 60% energy as fat and lower levels of calcium, 
      vitamin D(3), folic acid, choline bitartrate, and fiber) or HFW with EGCG (HFWE; 
      HFW with 0.32% EGCG) diet for 17 wks. As a comparison, two other groups of mice 
      fed a low-fat diet (LF; 10% energy as fat) and high-fat diet (HF; 60% energy as 
      fat) were also included. The HFW group developed more body weight gain and severe 
      symptoms of metabolic syndrome than the HF group. The EGCG treatment 
      significantly reduced body weight gain associated with increased fecal lipids and 
      decreased blood glucose and alanine aminotransferase (ALT) levels compared to 
      those of the HFW group. Fatty liver incidence, liver damage, and liver 
      triglyceride levels were also decreased by the EGCG treatment. Moreover, the EGCG 
      treatment attenuated insulin resistance and levels of plasma cholesterol, 
      monocyte chemoattractant protein-1 (MCP-1), C-reactive protein (CRP), 
      interlukin-6 (IL-6), and granulocyte colony-stimulating factor (G-CSF). Our 
      results demonstrate that the HFW diet produces more severe symptoms of metabolic 
      syndrome than the HF diet and that the EGCG treatment can alleviate these 
      symptoms and body fat accumulation. The beneficial effects of EGCG are associated 
      with decreased lipid absorption and reduced levels of inflammatory cytokines.
FAU - Chen, Yu-Kuo
AU  - Chen YK
AD  - Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The 
      State University of New Jersey, Piscataway, New Jersey 08854, United States.
FAU - Cheung, Connie
AU  - Cheung C
FAU - Reuhl, Kenneth R
AU  - Reuhl KR
FAU - Liu, Anna Ba
AU  - Liu AB
FAU - Lee, Mao-Jung
AU  - Lee MJ
FAU - Lu, Yao-Ping
AU  - Lu YP
FAU - Yang, Chung S
AU  - Yang CS
LA  - eng
GR  - P30 ES005022/ES/NIEHS NIH HHS/United States
GR  - R01 CA133021/CA/NCI NIH HHS/United States
GR  - P30 CA072720-13/CA/NCI NIH HHS/United States
GR  - R01 CA122474/CA/NCI NIH HHS/United States
GR  - R01 CA120915/CA/NCI NIH HHS/United States
GR  - R01 CA133021-04/CA/NCI NIH HHS/United States
GR  - P30 CA072720/CA/NCI NIH HHS/United States
GR  - ES05022/ES/NIEHS NIH HHS/United States
GR  - P30 ES005022-15/ES/NIEHS NIH HHS/United States
GR  - R01 CA120915-02S1/CA/NCI NIH HHS/United States
GR  - CA120915-S2/CA/NCI NIH HHS/United States
GR  - R01 CA120915-04/CA/NCI NIH HHS/United States
GR  - CA72720/CA/NCI NIH HHS/United States
GR  - R01 CA122474-04/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20111018
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Blood Glucose)
RN  - 0 (Plant Extracts)
RN  - 0 (Polyphenols)
RN  - 8R1V1STN48 (Catechin)
RN  - BQM438CTEL (epigallocatechin gallate)
SB  - IM
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Body Weight/drug effects
MH  - Catechin/administration & dosage/*analogs & derivatives
MH  - Diet, High-Fat/*adverse effects
MH  - Disease Models, Animal
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/*drug therapy/metabolism/physiopathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Obesity/*drug therapy/metabolism/physiopathology
MH  - Plant Extracts/*administration & dosage
MH  - Polyphenols/*administration & dosage
PMC - PMC3243651
MID - NIHMS332936
EDAT- 2011/09/22 06:00
MHDA- 2012/02/23 06:00
PMCR- 2012/11/09
CRDT- 2011/09/22 06:00
PHST- 2011/09/22 06:00 [entrez]
PHST- 2011/09/22 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
PHST- 2012/11/09 00:00 [pmc-release]
AID - 10.1021/jf2029016 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2011 Nov 9;59(21):11862-71. doi: 10.1021/jf2029016. Epub 2011 
      Oct 18.