PMID- 21934621
OWN - NLM
STAT- MEDLINE
DCOM- 20120104
LR  - 20161125
IS  - 1473-6578 (Electronic)
IS  - 0951-7367 (Linking)
VI  - 24
IP  - 6
DP  - 2011 Nov
TI  - Pharmacological treatment of dementia and mild cognitive impairment due to 
      Alzheimer's disease.
PG  - 556-61
LID - 10.1097/YCO.0b013e32834b7b96 [doi]
AB  - PURPOSE OF REVIEW: To give an overview of recent developments in pharmacological 
      treatment options of cognitive as well as behavioural and psychological symptoms 
      of dementia (BPSD) associated with Alzheimer's disease (AD) dementia and mild 
      cognitive impairment due to AD (MCI-AD). RECENT FINDINGS: Knowledge about the 
      efficacy and limitations of the antidementive drugs memantine and cholinesterase 
      inhibitors (ChEIs) in different stages of AD is further expanding. The prediction 
      of treatment response to ChEI and assessment of treatment outcome in the 
      individual patient remain unsolved issues. Commonly prescribed antidepressants 
      have recently failed to be beneficial in depressed AD dementia patients. Clinical 
      trials on new disease-modifying drugs have been disappointing so far. SUMMARY: 
      There is an urgent need for more effective treatment options for cognitive 
      symptoms and BPSD in AD dementia and MCI-AD and for disease-modifying drugs to 
      stop the underlying neurodegenerative process. Recently published new research 
      criteria for the diagnosis of AD enlarge the window for the detection of the 
      disease to early, predementia stages and include biomarkers related to the 
      underlying cerebral AD pathology. In future studies, these criteria will 
      hopefully facilitate the identification of effective drugs in early AD stages.
FAU - Popp, Julius
AU  - Popp J
AD  - Division of Old Age Psychiatry, Department of Psychiatry, University Hospital of 
      Lausanne, Lausanne, Switzerland.
FAU - Arlt, Sonke
AU  - Arlt S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Psychiatry
JT  - Current opinion in psychiatry
JID - 8809880
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Cholinesterase Inhibitors)
RN  - 0 (Dopamine Agents)
SB  - IM
MH  - Alzheimer Disease/*complications/drug therapy
MH  - Antipsychotic Agents/*therapeutic use
MH  - Cholinesterase Inhibitors/*therapeutic use
MH  - Cognitive Dysfunction/*drug therapy
MH  - Dementia/*drug therapy
MH  - Dopamine Agents/*therapeutic use
MH  - Humans
EDAT- 2011/09/22 06:00
MHDA- 2012/01/05 06:00
CRDT- 2011/09/22 06:00
PHST- 2011/09/22 06:00 [entrez]
PHST- 2011/09/22 06:00 [pubmed]
PHST- 2012/01/05 06:00 [medline]
AID - 10.1097/YCO.0b013e32834b7b96 [doi]
PST - ppublish
SO  - Curr Opin Psychiatry. 2011 Nov;24(6):556-61. doi: 10.1097/YCO.0b013e32834b7b96.