PMID- 21936716
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20120723
IS  - 1931-8405 (Electronic)
IS  - 0889-2229 (Linking)
VI  - 28
IP  - 8
DP  - 2012 Aug
TI  - Correlation of prospective and cross-sectional measures of HIV type 1 incidence 
      in a higher-risk cohort in Ho Chi Minh City, Vietnam.
PG  - 866-73
AB  - The primary aim of this study was to estimate HIV incidence within a high-risk 
      population in Ho Chi Minh City (HCMC), Vietnam using both cross-sectional and 
      prospective methodologies. A secondary aim was to develop a local correction 
      factor for the BED and avidity index incidence assays. The research study design 
      consisted of three phases: (1) cross-sectional, (2) prospective, and (3) BED 
      false recent (BED FR). A total of 1619 high-risk, sexually active individuals 
      were enrolled in the cross-sectional phase and 355 of the opiate-negative, 
      HIV-negative women were subsequently enrolled in the prospective phase. 
      Four-hundred and three men and women with known HIV infection duration of greater 
      than 12 months were enrolled in the BED FR phase. The HIV prevalence for all 
      participants in the cross-sectional phase was 15.8%. HIV incidence in the 
      cross-sectional group was estimated using the BED IgG capture assay and AxSYM 
      avidity index assay for recent HIV infection and incidence within the prospective 
      cohort was determined by observations of HIV seroconversion. HIV incidence in 
      opiate-negative women was estimated using the BED assay to be 0.8% unadjusted and 
      0.5% after applying the locally derived BED false recent rate of 1.7%; no 
      seroconversions were observed in the prospective cohort. We also screened the 
      cross-sectional samples for evidence of acute infection using nucleic acid 
      testing, 4th generation HIV EIA, and SMARTube coupled with Genscreen and 
      Determine diagnostic tests; no confirmed acute infections were identified by any 
      method. HIV incidence within this opiate-negative study population was low and 
      incidence estimates from the two methods compared favorably with each other. 
      Incidence estimates and false recent rates using the AxSYM assay were higher: AI 
      FRR of 2.7% and adjusted incidence of 1.7% per year (95% CI, 0.6, 2.8). By 
      comparison, both HIV prevalence and incidence estimates for the opiate-positive 
      group were higher.
FAU - Sexton, Connie J
AU  - Sexton CJ
AD  - FHI, Research Triangle Park, North Carolina 27709, USA.
FAU - Costenbader, Elizabeth C
AU  - Costenbader EC
FAU - Vinh, Dang Thi Nhat
AU  - Vinh DT
FAU - Chen, Pai Lien
AU  - Chen PL
FAU - Hoang, Tran Vu
AU  - Hoang TV
FAU - Lan, Nguyen Thi Hoang
AU  - Lan NT
FAU - Feldblum, Paul
AU  - Feldblum P
FAU - Kim, Andrea
AU  - Kim A
FAU - Giang, Le Truong
AU  - Giang le T
LA  - eng
GR  - 200-20074-05314/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20111109
PL  - United States
TA  - AIDS Res Hum Retroviruses
JT  - AIDS research and human retroviruses
JID - 8709376
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - HIV Infections/diagnosis/*epidemiology
MH  - HIV Seropositivity/*epidemiology
MH  - *HIV Seroprevalence
MH  - *HIV-1
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Prospective Studies
MH  - Risk Factors
MH  - Vietnam/epidemiology
MH  - Young Adult
EDAT- 2011/09/23 06:00
MHDA- 2013/05/23 06:00
CRDT- 2011/09/23 06:00
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 10.1089/aid.2011.0221 [doi]
PST - ppublish
SO  - AIDS Res Hum Retroviruses. 2012 Aug;28(8):866-73. doi: 10.1089/aid.2011.0221. 
      Epub 2011 Nov 9.