PMID- 21936915
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 13
IP  - 1
DP  - 2011 Sep 21
TI  - Prevalence of scarred and dysfunctional myocardium in patients with heart failure 
      of ischaemic origin: a cardiovascular magnetic resonance study.
PG  - 53
LID - 10.1186/1532-429X-13-53 [doi]
AB  - BACKGROUND: Cardiovascular magnetic resonance (CMR) with late gadolinium 
      enhancement (LGE) can provide unique data on the transmural extent of 
      scar/viability. We assessed the prevalence of dysfunctional myocardium, including 
      partial thickness scar, which could contribute to left ventricular contractile 
      dysfunction in patients with heart failure and ischaemic heart disease who denied 
      angina symptoms. METHODS: We invited patients with ischaemic heart disease and a 
      left ventricular ejection fraction < 50% by echocardiography to have LGE CMR. 
      Myocardial contractility and transmural extent of scar were assessed using a 
      17-segment model. RESULTS: The median age of the 193 patients enrolled was 70 
      (interquartile range: 63-76) years and 167 (87%) were men. Of 3281 myocardial 
      segments assessed, 1759 (54%) were dysfunctional, of which 581 (33%) showed no 
      scar, 623 (35%) had scar affecting </=50% of wall thickness and 555 (32%) had scar 
      affecting > 50% of wall thickness. Of 1522 segments with normal contractile 
      function, only 98 (6%) had evidence of scar on CMR. Overall, 182 (94%) patients 
      had >/=1 and 107 (55%) patients had >/=5 segments with contractile dysfunction that 
      had no scar or </=50% transmural scar suggesting viability. CONCLUSIONS: In this 
      cohort of patients with left ventricular systolic dysfunction and ischaemic heart 
      disease, about half of all segments had contractile dysfunction but only one 
      third of these had > 50% of the wall thickness affected by scar, suggesting that 
      most dysfunctional segments could improve in response to an appropriate 
      intervention.
FAU - Bourantas, Christos V
AU  - Bourantas CV
AD  - Department of Cardiology, Academic Unit, University of Hull, Postgraduate Medical 
      Institute, Kingston-upon-Hull, UK. cbourantas@gmail.com
FAU - Nikitin, Nikolay P
AU  - Nikitin NP
FAU - Loh, Huan P
AU  - Loh HP
FAU - Lukaschuk, Elena I
AU  - Lukaschuk EI
FAU - Sherwi, Nassar
AU  - Sherwi N
FAU - de Silva, Ramesh
AU  - de Silva R
FAU - Tweddel, Ann C
AU  - Tweddel AC
FAU - Alamgir, Mohamed F
AU  - Alamgir MF
FAU - Wong, Kenneth
AU  - Wong K
FAU - Gupta, Sanjay
AU  - Gupta S
FAU - Clark, Andrew L
AU  - Clark AL
FAU - Cleland, John Gf
AU  - Cleland JG
LA  - eng
GR  - PG/04/038/16930/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110921
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
RN  - 84F6U3J2R6 (gadodiamide)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - Cicatrix/diagnosis/etiology
MH  - Contrast Media
MH  - Echocardiography
MH  - England
MH  - Female
MH  - Gadolinium DTPA
MH  - Heart Failure/*diagnosis/etiology/pathology/physiopathology
MH  - Humans
MH  - Linear Models
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction
MH  - Myocardial Ischemia/*complications
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Prospective Studies
MH  - Stroke Volume
MH  - Tissue Survival
MH  - Ventricular Dysfunction, Left/*diagnosis/etiology/pathology/physiopathology
MH  - Ventricular Function, Left
PMC - PMC3190338
EDAT- 2011/09/23 06:00
MHDA- 2011/12/24 06:00
PMCR- 2011/09/21
CRDT- 2011/09/23 06:00
PHST- 2011/02/26 00:00 [received]
PHST- 2011/09/21 00:00 [accepted]
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
PHST- 2011/09/21 00:00 [pmc-release]
AID - S1097-6647(23)01408-4 [pii]
AID - 1532-429X-13-53 [pii]
AID - 10.1186/1532-429X-13-53 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2011 Sep 21;13(1):53. doi: 10.1186/1532-429X-13-53.