PMID- 21937025
OWN - NLM
STAT- MEDLINE
DCOM- 20120803
LR  - 20191210
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1419
DP  - 2011 Oct 24
TI  - The synchronization of spontaneous BOLD activity predicts extraversion and 
      neuroticism.
PG  - 68-75
LID - 10.1016/j.brainres.2011.08.060 [doi]
AB  - There is an increasing body of evidence pointing to a relationship between 
      personality and brain markers. The purpose of this study was to identify the 
      associations between personality dimensions of extraversion and neuroticism and 
      the local synchronization of spontaneous blood oxygen level-dependent (BOLD) 
      activity assessed by regional homogeneity (ReHo) approach. Our results revealed 
      the significant negative correlation between neuroticism and ReHo in the left 
      middle frontal gyrus, providing evidence for the left frontal activation involved 
      in pleasant emotion. ReHo was correlated negatively with extraversion in the 
      medial prefrontal cortex (MPFC), an important portion of the default mode network 
      (DMN), thus further indicating the relationship between DMN and personality. In 
      addition, ReHo in the insula, cerebellum and cingulate gyrus was correlated 
      positively with extraversion, suggesting the associations between individual 
      difference in extraversion and specific brain regions involved in affective 
      processing. These findings shed light on the important relationship between the 
      synchronization of spontaneous fluctuations and personality dimensions of 
      extraversion and neuroticism, which provide further evidence for the neural 
      underpinning of individual difference in personality traits.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Wei, Luqing
AU  - Wei L
AD  - Key laboratory for Neuroinformation of Ministry of Education, School of Life 
      Science and Technology, University of Electronic Science and Technology of China, 
      Chengdu 610054, PR China.
FAU - Duan, Xujun
AU  - Duan X
FAU - Yang, Yang
AU  - Yang Y
FAU - Liao, Wei
AU  - Liao W
FAU - Gao, Qing
AU  - Gao Q
FAU - Ding, Ju-rong
AU  - Ding JR
FAU - Zhang, Zhiqiang
AU  - Zhang Z
FAU - Zeng, Weixi
AU  - Zeng W
FAU - Li, Yuan
AU  - Li Y
FAU - Lu, Guangming
AU  - Lu G
FAU - Chen, Huafu
AU  - Chen H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110830
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/*physiology
MH  - Brain Mapping/methods
MH  - *Extraversion, Psychological
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Neurotic Disorders/diagnosis/*physiopathology
MH  - Oxygen/*blood
MH  - Personality/*physiology
MH  - Predictive Value of Tests
MH  - Young Adult
EDAT- 2011/09/23 06:00
MHDA- 2012/08/04 06:00
CRDT- 2011/09/23 06:00
PHST- 2011/04/15 00:00 [received]
PHST- 2011/08/21 00:00 [revised]
PHST- 2011/08/24 00:00 [accepted]
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2012/08/04 06:00 [medline]
AID - S0006-8993(11)01587-3 [pii]
AID - 10.1016/j.brainres.2011.08.060 [doi]
PST - ppublish
SO  - Brain Res. 2011 Oct 24;1419:68-75. doi: 10.1016/j.brainres.2011.08.060. Epub 2011 
      Aug 30.