PMID- 21939427
OWN - NLM
STAT- MEDLINE
DCOM- 20120813
LR  - 20131106
IS  - 1744-7607 (Electronic)
IS  - 1742-5255 (Linking)
VI  - 7
IP  - 11
DP  - 2011 Nov
TI  - An update on computational oral absorption simulation.
PG  - 1345-64
LID - 10.1517/17425255.2011.617743 [doi]
AB  - INTRODUCTION: Within the last decades, computational models have developed 
      rapidly and some of these models have proven useful in understanding how 
      physiological, physicochemical and formulation factors affect oral drug 
      absorption. Nowadays, complex computer-based absorption models are being used as 
      standard tools in both academia and the pharmaceutical industry at several stages 
      of the drug development process. AREAS COVERED: Areas covered include the 
      progress of computational tools for predicting drug absorption. The various 
      qualitative and quantitative approaches that have been proposed are summarized, 
      with special emphasis on a key tool for predicting oral drug absorption, 
      physiologically based pharmacokinetic modeling (PBPK). The theories of the 
      different models are described and recent applications within drug research and 
      development are summarized and evaluated. Additionally, the current state of 
      computational absorption models is discussed, including areas for potential 
      improvements. EXPERT OPINION: The field of pharmacokinetics modeling has 
      undergone a major transformation over the last 10 - 20 years and there will most 
      likely be even more exciting developments ahead. With the availability of generic 
      physiologically based absorption models, more and more case examples using PBPK 
      models have been published that demonstrate either improved ability to predict 
      oral drug absorption or have allowed a more mechanistic interpretation of 
      experimentally observed data.
FAU - Dressman, Jennifer B
AU  - Dressman JB
AD  - Johann Wolfgang Goethe University, Institute of Pharmaceutical Technology, 
      Biocenter, Germany. dressman@em.uni-frankfurt.de
FAU - Thelen, Kirstin
AU  - Thelen K
FAU - Willmann, Stefan
AU  - Willmann S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110923
PL  - England
TA  - Expert Opin Drug Metab Toxicol
JT  - Expert opinion on drug metabolism & toxicology
JID - 101228422
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Administration, Oral
MH  - Computer Simulation/*trends
MH  - Humans
MH  - Models, Chemical
MH  - Pharmaceutical Preparations/*metabolism
MH  - *Pharmacokinetics
MH  - Physiological Phenomena
EDAT- 2011/09/24 06:00
MHDA- 2012/08/14 06:00
CRDT- 2011/09/24 06:00
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2012/08/14 06:00 [medline]
AID - 10.1517/17425255.2011.617743 [doi]
PST - ppublish
SO  - Expert Opin Drug Metab Toxicol. 2011 Nov;7(11):1345-64. doi: 
      10.1517/17425255.2011.617743. Epub 2011 Sep 23.