PMID- 21939467
OWN - NLM
STAT- MEDLINE
DCOM- 20120827
LR  - 20220311
IS  - 1525-1403 (Electronic)
IS  - 1094-7159 (Print)
IS  - 1094-7159 (Linking)
VI  - 14
IP  - 6
DP  - 2011 Nov-Dec
TI  - Deep brain stimulation for early-stage Parkinson's disease: an illustrative case.
PG  - 515-21; discussion 521-2
LID - 10.1111/j.1525-1403.2011.00391.x [doi]
AB  - OBJECTIVES: Subthalamic nucleus (STN) deep brain stimulation (DBS) is an 
      effective intervention in advanced Parkinson's disease (PD), but its efficacy and 
      safety in early PD are unknown. We are conducting a randomized pilot trial 
      investigating DBS in early PD. This report describes one participant who received 
      bilateral STN-DBS. MATERIALS AND METHODS: Thirty subjects have been randomized to 
      either optimal drug therapy (ODT) or DBS + ODT. Microelectrode recordings from 
      the STN and substantia nigra are collected at implantation. The Unified 
      Parkinson's Disease Rating Scale Motor Subscale (UPDRS-III) is administered in 
      the ON and OFF states semi-annually and neuropsychological function and quality 
      of life are assessed annually. We describe a 54-year-old man with a two-year 
      history of PD who was randomized to DBS + ODT and followed for two years. 
      RESULTS: The subject showed a lower STN to substantia nigra ratio of neuronal 
      activity than advanced PD patients, and higher firing rate than non-PD patients. 
      The subject's total UPDRS and UPDRS-III scores improved during the two-year 
      follow-up, while his OFF UPDRS-III score and levodopa equivalent daily dose 
      increased. Quality of life, verbal fluency, and verbal learning improved. He did 
      not experience any serious adverse events. CONCLUSIONS: This report details the 
      first successful application of bilateral STN-DBS for early-stage PD during a 
      clinical trial.
CI  - (c) 2011 International Neuromodulation Society.
FAU - Gill, Chandler E
AU  - Gill CE
AD  - Stritch School of Medicine, Loyola University, Maywood, IL, USA.
FAU - Allen, Laura A
AU  - Allen LA
FAU - Konrad, Peter E
AU  - Konrad PE
FAU - Davis, Thomas L
AU  - Davis TL
FAU - Bliton, Mark J
AU  - Bliton MJ
FAU - Finder, Stuart G
AU  - Finder SG
FAU - Tramontana, Michael G
AU  - Tramontana MG
FAU - Kao, C Chris
AU  - Kao CC
FAU - Remple, Michael S
AU  - Remple MS
FAU - Bradenham, Courtney H
AU  - Bradenham CH
FAU - Charles, P David
AU  - Charles PD
LA  - eng
GR  - UL1 RR024975-01/RR/NCRR NIH HHS/United States
GR  - TL1 RR024978/RR/NCRR NIH HHS/United States
GR  - KL2 RR024977/RR/NCRR NIH HHS/United States
GR  - 1 UL1RR024975/RR/NCRR NIH HHS/United States
GR  - UL1 RR024975/RR/NCRR NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110921
PL  - United States
TA  - Neuromodulation
JT  - Neuromodulation : journal of the International Neuromodulation Society
JID - 9804159
SB  - IM
MH  - Aged
MH  - Deep Brain Stimulation/*methods
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*diagnosis/psychology/*therapy
MH  - Pilot Projects
PMC - PMC3237808
MID - NIHMS317234
COIS- Conflict of Interest: The clinical trial from which this case is reported is 
      funded by Medtronic, Inc., by Vanderbilt CTSA grant 1 UL1 RR024975 from the 
      NCRR-NIH, and by private donations. Medtronic representatives did not take part 
      in data collection, management, analysis, or interpretation of the data or in 
      preparation, review, or approval of the manuscript. Drs. Charles, Davis, Konrad 
      and Kao have received personal compensation from Medtronic in the past. 
      Vanderbilt University has received grants from Medtronic in excess of $10,000to 
      support research led by Drs. Charles and Konrad. Ms. Gill, Ms. Allen, Dr. 
      Harrison, Dr. Finder, Dr. Tramontana, Dr. Remple and Dr. Bliton have no conflicts 
      to disclose.
EDAT- 2011/09/24 06:00
MHDA- 2012/08/28 06:00
PMCR- 2012/11/01
CRDT- 2011/09/24 06:00
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2012/08/28 06:00 [medline]
PHST- 2012/11/01 00:00 [pmc-release]
AID - S1094-7159(11)60348-6 [pii]
AID - 10.1111/j.1525-1403.2011.00391.x [doi]
PST - ppublish
SO  - Neuromodulation. 2011 Nov-Dec;14(6):515-21; discussion 521-2. doi: 
      10.1111/j.1525-1403.2011.00391.x. Epub 2011 Sep 21.