PMID- 21940050
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20111031
IS  - 1872-9142 (Electronic)
IS  - 0161-5890 (Linking)
VI  - 49
IP  - 1-2
DP  - 2011 Oct
TI  - Characterization of circulating and monocyte-derived dendritic cells in obese and 
      diabetic patients.
PG  - 234-8
LID - 10.1016/j.molimm.2011.08.019 [doi]
AB  - Dendritic cells (DCs) are suspected to be involved in the development of 
      atherogenesis, but their role is still unclear. The aim of this study was to 
      characterize circulating DCs and monocyte-derived DCs (Mo-DCs) of obese and 
      diabetic patients (T2D), and to study their interaction with human coronary 
      smooth muscle cells (CASMCs). Obese post-menopausal women with or without insulin 
      resistance were enrolled and were compared to age-matched healthy women. Myeloid 
      circulating DCs significantly increased in obese T2D patients compared to healthy 
      donors and a smaller increase was observed for plasmacytoid one. Mature Mo-DCs 
      from obese T2D patients significantly decreased when compared to control, but 
      they were significantly more capable of adhering to CASMCs compared to that from 
      healthy controls and from not-T2D obese subjects. Altogether these data suggest 
      that in conditions of insulin-resistance and obesity there is an up-regulation of 
      myeloid DCs that might contribute to pathological vascular remodeling.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Musilli, Claudia
AU  - Musilli C
AD  - Department of Preclinical and Clinical Pharmacology, University of Florence, 
      Viale Pieraccini 6-50139, Florence, Italy.
FAU - Paccosi, Sara
AU  - Paccosi S
FAU - Pala, Laura
AU  - Pala L
FAU - Gerlini, Gianni
AU  - Gerlini G
FAU - Ledda, Fabrizio
AU  - Ledda F
FAU - Mugelli, Alessandro
AU  - Mugelli A
FAU - Rotella, Carlo Maria
AU  - Rotella CM
FAU - Parenti, Astrid
AU  - Parenti A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110921
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
SB  - IM
MH  - Aged
MH  - Cell Adhesion/immunology
MH  - Coronary Vessels/pathology
MH  - Dendritic Cells/cytology/*immunology
MH  - Diabetes Mellitus, Type 2/blood/*immunology/pathology
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Insulin Resistance/immunology
MH  - Monocytes/cytology/immunology
MH  - Muscle, Smooth, Vascular/pathology
MH  - Obesity/blood/*immunology/pathology
MH  - Stem Cells/cytology/immunology
EDAT- 2011/09/24 06:00
MHDA- 2011/12/21 06:00
CRDT- 2011/09/24 06:00
PHST- 2011/06/29 00:00 [received]
PHST- 2011/08/23 00:00 [revised]
PHST- 2011/08/25 00:00 [accepted]
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
AID - S0161-5890(11)00734-6 [pii]
AID - 10.1016/j.molimm.2011.08.019 [doi]
PST - ppublish
SO  - Mol Immunol. 2011 Oct;49(1-2):234-8. doi: 10.1016/j.molimm.2011.08.019. Epub 2011 
      Sep 21.