PMID- 21940322
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20111117
IS  - 0172-6390 (Print)
IS  - 0172-6390 (Linking)
VI  - 58
IP  - 110-111
DP  - 2011 Sep-Oct
TI  - Effect of proton pump inhibitor (PPI) treatment in obstructive sleep apnea 
      syndrome: an esophageal impedance-pHmetry study.
PG  - 1566-73
LID - 10.5754/hge10465 [doi]
AB  - BACKGROUND/AIMS: There is an increasing interest for a link between 
      gastroesophageal reflux (GER) and obstructive sleep apnea syndrome (OSAS). There 
      is no study in the literature which examines the relationship between OSAS and 
      esophageal functions in adults with impedance. We first evaluated the role of 
      reflux in OSAS with simultaneous polysomnography and impedance-pHmetry and then 
      investigated whether the effect of proton pump inhibitor (PPI) treatment changes 
      in these parameters. METHODOLOGY: Twenty two OSAS patients who had applied to 
      sleep laboratory between September 2007 and May 2008 were consecutively enrolled 
      to the study. Twenty four hours esophageal impedance study was performed during 
      polysomnographic recording. At least 50% of all apneas in patients must proceed 
      with a reflux event in 2 minute intervals in order to be considered reflux 
      related apnea patient. RESULTS: Pathologic reflux episodes were determined in 20 
      patients (8 were weakly acidic, 12 were acidic). Reflux dependent apnea was found 
      in 6 patients. There was endoscopically esophagitis in all reflux related apnea 
      patients. There was a negative correlation between initial mean SaO2 and gas 
      reflux events at night (p=0.004, r =-0.588) and mixed reflux events at night 
      (p=0.02, r=0.493). There was a statistically significant regression of AHI (apnea 
      hypopnea index) after 3-months PPI treatment (p=0.012). CONCLUSIONS: Reflux may 
      trigger apnea in some of the OSAS patients. Therefore, each OSAS patient must be 
      inquired about esophageal and extraesophageal symptoms of reflux.
FAU - Ermis, Fatih
AU  - Ermis F
AD  - Department of Gastroenterology, Istanbul University, Istanbul, Turkey. 
      fatihermis2@hotmail.com
FAU - Akyuz, Filiz
AU  - Akyuz F
FAU - Arici, Serpil
AU  - Arici S
FAU - Uyanikoglu, Ahmet
AU  - Uyanikoglu A
FAU - Yakar, Fatih
AU  - Yakar F
FAU - Pinarbasi, Binnur
AU  - Pinarbasi B
FAU - Demir, Kadir
AU  - Demir K
FAU - Ozdil, Sadakat
AU  - Ozdil S
FAU - Besisik, Fatih
AU  - Besisik F
FAU - Kaymakoglu, Sabahattin
AU  - Kaymakoglu S
FAU - Boztas, Gungor
AU  - Boztas G
FAU - Cuhadaroglu, Caglar
AU  - Cuhadaroglu C
FAU - Mungan, Zeynel
AU  - Mungan Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110715
PL  - Greece
TA  - Hepatogastroenterology
JT  - Hepato-gastroenterology
JID - 8007849
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Esophageal pH Monitoring
MH  - Esophagoscopy
MH  - Female
MH  - Gastroesophageal Reflux/*complications/diagnosis/*drug therapy/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polysomnography
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Sleep Apnea, Obstructive/*complications/diagnosis/physiopathology
MH  - Statistics, Nonparametric
MH  - Treatment Outcome
EDAT- 2011/09/24 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/09/24 06:00
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 10.5754/hge10465 [doi]
PST - ppublish
SO  - Hepatogastroenterology. 2011 Sep-Oct;58(110-111):1566-73. doi: 10.5754/hge10465. 
      Epub 2011 Jul 15.