PMID- 2194089
OWN - NLM
STAT- MEDLINE
DCOM- 19900806
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 46
IP  - 25
DP  - 1990
TI  - Leukotriene C4-induced release of LHRH into the hypophyseal portal blood and of 
      LH into the peripheral blood.
PG  - 1857-65
AB  - Intracerebroventricular (i.c.v.) administration of leukotriene (LT) C4 at doses 
      of 2, 0.5 and 0.2 micrograms/rat significantly stimulated (3-12 fold) the release 
      of LH into the peripheral blood of male rats. Injection of anti-LHRH serum had no 
      effect on LTC4-stimulated LH release, but did block PGE2- stimulated LH release. 
      I.c.v.- infused LTC4 also stimulated the release of LHRH into the hypophyseal 
      portal blood. This is the first report of an in vivo action of LTC4 on the 
      release of a hypothalamic releasing factor (LHRH) and a pituitary hormone (LH). 
      These observations, plus in vitro results, clearly show that LTC4 stimulates LH 
      release by acting on both the hypothalamus, causing LHRH release, and on the 
      pituitary. Then the action of LTC4 on LH release in vivo is quite different from 
      the indirect action of PGE2.
FAU - Saadi, M
AU  - Saadi M
AD  - Institut Pasteur, URIA, INSERM U 207, Paris, France.
FAU - Gerozissis, K
AU  - Gerozissis K
FAU - Rougeot, C
AU  - Rougeot C
FAU - Minary, P
AU  - Minary P
FAU - Dray, F
AU  - Dray F
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (SRS-A)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Animals
MH  - Dinoprostone/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Gonadotropin-Releasing Hormone/*blood/metabolism
MH  - Hypothalamus/*drug effects/metabolism
MH  - Injections, Intraventricular
MH  - Luteinizing Hormone/*blood/metabolism
MH  - Male
MH  - Pituitary Gland/*drug effects/metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - SRS-A/administration & dosage/*pharmacology
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 0024-3205(90)90238-M [pii]
AID - 10.1016/0024-3205(90)90238-m [doi]
PST - ppublish
SO  - Life Sci. 1990;46(25):1857-65. doi: 10.1016/0024-3205(90)90238-m.