PMID- 21940994
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20201222
IS  - 1530-6860 (Electronic)
IS  - 0892-6638 (Linking)
VI  - 26
IP  - 1
DP  - 2012 Jan
TI  - gamma-Interferon-regulated chaperone governs human lymphocyte antigen class II 
      expression.
PG  - 104-16
LID - 10.1096/fj.11-189670 [doi]
AB  - Antigen presentation by human lymphocyte antigen (HLA) class II peptide receptors 
      alerts the immune system to infections. In antigen-presenting cells (APCs), HLA 
      class II, HLA-DM, and associated invariant chain-encoding genes are exclusively 
      regulated by the interferon gamma (IFNgamma)-inducible class II transactivator (CIITA). 
      Control of CIITA expression could therefore govern expression of class II peptide 
      receptors in the diverse group of APCs. We discovered that elevation of the HLA 
      class III region encoded B-associated transcript 3 (BAT3) increases and depletion 
      of BAT3 decreases expression of HLA class II, HLA-DM, and invariant chain. IFNgamma 
      strongly elevates BAT3 transcription in various tumor cell lines and in primary 
      macrophages. BAT3 chaperones the simultaneously IFNgamma-induced CIITA. Following 
      IFNgamma-treatment, both CIITA and BAT3 translocate from the cytosol to the nucleus. 
      The nuclear import of CIITA mediated by IFNgamma controls activation of HLA class II 
      genes. BAT3 is a novel key regulator of components of the HLA class II processing 
      pathway. We present a mechanism explaining how parallel IFNgamma-mediated regulation 
      of CIITA and of its chaperone BAT3 controls the level of components of the HLA 
      class II processing pathway.
FAU - Kamper, Nadine
AU  - Kamper N
AD  - Institute of Genetics, University of Bonn, Bonn, Germany.
FAU - Franken, Sebastian
AU  - Franken S
FAU - Temme, Sebastian
AU  - Temme S
FAU - Koch, Susanne
AU  - Koch S
FAU - Bieber, Thomas
AU  - Bieber T
FAU - Koch, Norbert
AU  - Koch N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110922
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
RN  - 0 (BAG6 protein, human)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (MHC class II transactivator protein)
RN  - 0 (Molecular Chaperones)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Trans-Activators)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Antigen-Presenting Cells/immunology/metabolism
MH  - Cell Line, Tumor
MH  - Cell Nucleus/metabolism
MH  - Cytoplasm/metabolism
MH  - Fibroblasts/cytology/immunology/metabolism
MH  - Gene Expression/drug effects/immunology
MH  - Histocompatibility Antigens Class II/genetics/*metabolism
MH  - Humans
MH  - Interferon-gamma/*metabolism/pharmacology
MH  - Lung/cytology
MH  - Lymphocytes/immunology/*metabolism
MH  - Macrophages/cytology/immunology/metabolism
MH  - Melanoma
MH  - Molecular Chaperones/genetics/immunology/*metabolism
MH  - Nuclear Proteins/genetics/*metabolism
MH  - Primary Cell Culture
MH  - Promoter Regions, Genetic/physiology
MH  - RNA, Messenger/metabolism
MH  - Trans-Activators/genetics/*metabolism
EDAT- 2011/09/24 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/09/24 06:00
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - fj.11-189670 [pii]
AID - 10.1096/fj.11-189670 [doi]
PST - ppublish
SO  - FASEB J. 2012 Jan;26(1):104-16. doi: 10.1096/fj.11-189670. Epub 2011 Sep 22.