PMID- 21942114
OWN - NLM
STAT- MEDLINE
DCOM- 20111018
LR  - 20110927
IS  - 0043-3144 (Print)
IS  - 0043-3144 (Linking)
VI  - 60
IP  - 2
DP  - 2011 Mar
TI  - Dengue HLA associations in Jamaicans.
PG  - 126-31
AB  - BACKGROUND: Polymorphisms in the human leukocyte antigen (HLA) genes might 
      predispose certain individuals to dengue fever (DF) and the severe forms of the 
      disease: dengue haemorrhagic fever/ dengue shock syndrome (DHF/DSS). SUBJECTS AND 
      METHOD: A DNA-based HLA typing method was used to determine the HLA class I and 
      II alleles in 50 patients with dengue, including 45 cases of DF 5 cases of DHF 
      and 177 healthy individuals in Jamaica. RESULTS: HLA-A*24 and - DRbeta5*01/02 
      were significantly associated with dengue infection while possession of HLA-A*23, 
      -CW*04, -DQbeta*02, -DQbeta*03 and DQbeta*06 were protective. No other 
      significant associations were found after correction for the number of alleles 
      tested at each HLA-locus. CONCLUSION: This is the first study to report a 
      significant association with HLA-A*24 and DF although this allele is associated 
      with DHF and DSS in Vietnamese patients. The other HLA associations observed in 
      the Jamaican cohort also are different from those reported in other ethnic 
      groups. Further studies which involve larger numbers of patients with DHF and 
      explore functional aspects of HLA allelic associations with dengue in Jamaicans 
      are necessary.
FAU - Brown, M G
AU  - Brown MG
AD  - Department of Microbiology, The University of the West Indies, Kingston 7, 
      Jamaica. michelle.brown@uwimona.edu.jm
FAU - Salas, R A
AU  - Salas RA
FAU - Vickers, I E
AU  - Vickers IE
FAU - Heslop, O D
AU  - Heslop OD
FAU - Smikle, M F
AU  - Smikle MF
LA  - eng
PT  - Journal Article
PL  - Jamaica
TA  - West Indian Med J
JT  - The West Indian medical journal
JID - 0417410
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Dengue/*immunology
MH  - *Disease Susceptibility
MH  - Gene Frequency
MH  - HLA Antigens/*analysis/genetics
MH  - Humans
MH  - Infant
MH  - Jamaica
MH  - Middle Aged
MH  - Young Adult
EDAT- 2011/09/29 06:00
MHDA- 2011/10/19 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2011/10/19 06:00 [medline]
AID - 1375 [pii]
PST - ppublish
SO  - West Indian Med J. 2011 Mar;60(2):126-31.