PMID- 21945778
OWN - NLM
STAT- MEDLINE
DCOM- 20140512
LR  - 20110928
IS  - 1673-4254 (Print)
IS  - 1673-4254 (Linking)
VI  - 31
IP  - 9
DP  - 2011 Sep
TI  - [Rapid detection of chromosome number aberration in spontaneously aborted fetuses 
      using fluorescence in situ hybridization].
PG  - 1605-7
AB  - OBJECTIVE: To assess the value of fluorescence in situ hybridization (FISH) in 
      the diagnosis of common chromosome number aberration in spontaneously aborted 
      fetuses. METHOD: A total of 100 spontaneously aborted fetuses were analyzed by 
      G-banding and by FISH to test chromosome number aberration mainly for chromosomes 
      13, 18, 21, X and Y, and the results of FISH test was assessed according to those 
      by G-banding test. RESULTS: FISH results were well consistent with those by 
      G-banding test. FISH test identified trisomy in 32 samples and polyploidy in 7 
      samples. Two samples with cell culture failure were found to have trisomy 16 by 
      FISH. Discrepancies in the results between the two tests occurred in 3 samples, 
      but the results of FISH were verified by other methods. Kappa test between FISH 
      technology and G-banding showed a good consistency between FISH and karyotyping 
      (P<0.05). CONCLUSION: FISH is an effective and rapid method for detecting 
      chromosome number aberration in spontaneously aborted fetuses, and the 
      combination of FISH and karyotyping provides more reliable diagnostic evidence.
FAU - Song, Lan-lin
AU  - Song LL
AD  - Department of Obstetrics and Gynecology, Southern Medical University, Guangzhou 
      510515, China.
FAU - Xiong, Li
AU  - Xiong L
FAU - Liu, Si-ping
AU  - Liu SP
FAU - Liu, Jie
AU  - Liu J
FAU - Zhong, Mei
AU  - Zhong M
FAU - Gao, Yun-fei
AU  - Gao YF
FAU - Wu, Rui-feng
AU  - Wu RF
FAU - Yu, Yan-hong
AU  - Yu YH
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
SB  - IM
MH  - *Aborted Fetus
MH  - *Chromosome Aberrations
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Karyotyping
MH  - Pregnancy
EDAT- 2011/09/29 06:00
MHDA- 2014/05/13 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2014/05/13 06:00 [medline]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2011 Sep;31(9):1605-7.