PMID- 21946743
OWN - NLM
STAT- MEDLINE
DCOM- 20111208
LR  - 20151119
IS  - 1175-8716 (Electronic)
IS  - 0028-8446 (Linking)
VI  - 124
IP  - 1336
DP  - 2011 Jun 10
TI  - Quetiapine for the treatment of behavioural and psychological symptoms of 
      dementia (BPSD): a meta-analysis of randomised placebo-controlled trials.
PG  - 39-50
AB  - AIM: This meta-analysis is aimed to determine the efficacy of quetiapine for the 
      treatment of behavioural and psychological symptoms of dementia (BPSD). METHOD: 
      Our electronic search included MEDLINE (1950-2009), Cochrane Central Register of 
      Controlled Trials and PsychINFO. We also did a hand search of the International 
      Psychogeriatric Association poster presentations and checked the National trial 
      registry data bases from USA, UK, RSA, Holland, Australia and New Zealand. We 
      included double-blinded randomised placebo-controlled trials studies that 
      measured BPSD with the Neuropsychiatric Inventory (NPI). The Clinical Global 
      Impression of Change scale (CGI-C) was our secondary outcome. RESULTS: Six sets 
      of data were included in this meta-analysis. Patients receiving quetiapine 
      improved when compared to placebo with a weighted mean difference of - 3.05 (95% 
      CI: -6.10, -0.01) and -0.31 (95% CI: -0.54, -0.08) respectively on the NPI score 
      and CGI-C score. CONCLUSION: This meta-analysis found that quetiapine is 
      statistically more efficacious than placebo in the treatment of BPSD as measured 
      by the NPI and CGI-C. However, improvement is of a small magnitude and observable 
      clinical significance is questionable.
FAU - Cheung, Gary
AU  - Cheung G
AD  - Mental Health Services for Older People, Auckland District Health Board, Private 
      Bag 92189, Greenlane Clinical Centre, Auckland, New Zealand. GCheung@adhb.govt.nz
FAU - Stapelberg, Janli
AU  - Stapelberg J
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20110610
PL  - New Zealand
TA  - N Z Med J
JT  - The New Zealand medical journal
JID - 0401067
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Dibenzothiazepines)
RN  - 2S3PL1B6UJ (Quetiapine Fumarate)
SB  - IM
MH  - Antipsychotic Agents/*therapeutic use
MH  - Behavior
MH  - Dementia/*drug therapy/*psychology
MH  - Dibenzothiazepines/*therapeutic use
MH  - Humans
MH  - Quetiapine Fumarate
MH  - Randomized Controlled Trials as Topic
EDAT- 2011/09/29 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - epublish
SO  - N Z Med J. 2011 Jun 10;124(1336):39-50.