PMID- 21947961
OWN - NLM
STAT- MEDLINE
DCOM- 20120504
LR  - 20221207
IS  - 1559-0283 (Electronic)
IS  - 1085-9195 (Linking)
VI  - 62
IP  - 1
DP  - 2012 Jan
TI  - Hyperhomocysteinemia and related genetic polymorphisms correlate with ulcerative 
      colitis in Chinese Han population in Central China [corrected].
PG  - 203-10
LID - 10.1007/s12013-011-9283-4 [doi]
AB  - Increased levels of homocysteine are found systemically and in intestinal mucosa 
      of patients with inflammatory bowel disease, and, specifically, in ulcerative 
      colitis (UC). However, there are controversial reports regarding the factors 
      contributing to increased levels of homocysteine in UC. Furthermore, little 
      information is available regarding the relationship between hyperhomocysteinemia 
      (HHcy), vitamin status, and genetic polymorphisms of homocysteine-related enzymes 
      in these patients. This study examined four functional polymorphisms linked to 
      homocysteine metabolism (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G), and 
      evaluated plasma levels of homocysteine, folate, and vitamin B(12) in 310 
      consecutive patients with UC and 936 age- and sex-matched healthy controls from 
      southeast China. The variant allele and genotypic frequencies in MTHFR A1298C, 
      MTR A2756G and MTRR A66G genes were significantly higher in patients with UC 
      compared to healthy controls. Further, HHcy and low levels of folate and vitamin 
      B(12) were more frequent in patients with UC. The MTR 2756G allele, extent of the 
      disease, and gender were the independent determinants of HHcy in these patients. 
      These findings suggest that genetic and nutritional factors have a synergetic 
      effect on HHcy in patients with UC. In conclusion, our data highlight a 
      prevention strategy for moderation of HHcy and supplementation with folate and 
      vitamine B(12) in patients with UC from Southeast China.
FAU - Jiang, Yi
AU  - Jiang Y
AD  - Department of Gastroenterology, Second Affiliated Hospital of Wenzhou Medical 
      College, Wenzhou, People's Republic of China.
FAU - Xia, Xuanping
AU  - Xia X
FAU - Wang, Wenxing
AU  - Wang W
FAU - Lin, Limiao
AU  - Lin L
FAU - Xu, Changlong
AU  - Xu C
FAU - Cai, Zhenzai
AU  - Cai Z
FAU - Zheng, Bo
AU  - Zheng B
FAU - Pei, Jihua
AU  - Pei J
FAU - Shen, Sujian
AU  - Shen S
FAU - Xia, Bing
AU  - Xia B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Biochem Biophys
JT  - Cell biochemistry and biophysics
JID - 9701934
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
RN  - EC 1.18.1.- (methionine synthase reductase)
RN  - EC 1.18.1.2 (Ferredoxin-NADP Reductase)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
RN  - EC 2.1.1.13 (5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
EIN - Cell Biochem Biophys. 2012 Mar;62(2):407
MH  - 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/*genetics
MH  - Adult
MH  - Alleles
MH  - Amino Acid Substitution
MH  - Asian People/*genetics
MH  - China
MH  - *Colitis, Ulcerative/complications/enzymology/genetics
MH  - Female
MH  - Ferredoxin-NADP Reductase/*genetics
MH  - Folic Acid/blood
MH  - Gene Frequency
MH  - Genotype
MH  - Homocysteine/blood/metabolism
MH  - Humans
MH  - *Hyperhomocysteinemia/complications/genetics
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Risk Factors
MH  - Vitamin B 12/blood
EDAT- 2011/09/29 06:00
MHDA- 2012/05/05 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/05/05 06:00 [medline]
AID - 10.1007/s12013-011-9283-4 [doi]
PST - ppublish
SO  - Cell Biochem Biophys. 2012 Jan;62(1):203-10. doi: 10.1007/s12013-011-9283-4.