PMID- 21949999
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20110928
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 25
IP  - 12
DP  - 2011 Jun
TI  - [Expression of programmed cell death 4 protein is closely correlated with 
      laryngeal squamous cell carcinomas].
PG  - 539-41
AB  - OBJECTIVE: To study whether programmed cell death 4 (PDCD4) is involved in the 
      development and progression of laryngeal squamous cell carcinomas (LSCC). METHOD: 
      The expressions of PDCD4 protein were examined by immunohistochemical staining 
      and Western blot in LSCC tissues and their surrounding laryngeal normal mucosa 
      tissues. RESULT: The positive rate of PDCD4 protein in LSCC was significantly 
      lower than that in the laryngeal normal mucosa tissues by immunohistochemical 
      staining (P<0.01). No correlation was found between positive expression of PDCD4 
      and gender, age, tumor site, TNM stage, but there was significant correlation 
      between positive expression of PDCD4 from differentiation grading and lymphatic 
      matastasis. Meanwhile,we got the similar results by Western blot (P<0.01). 
      CONCLUSION: The low expression of PDCD4 protein is closely related to the 
      development and progression of LSCC. PDCD4 might be a novel molecular marker for 
      prognosticating metastases and prognosis of LSCC.
FAU - Wang, Jianting
AU  - Wang J
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Beijing Chaoyang 
      Hospital, Capital Medical University, Beijing, 100020, China. 
      tingjianwang@yahoo.com.cn
FAU - Zhang, Yuxiang
AU  - Zhang Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (PDCD4 protein, human)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Apoptosis Regulatory Proteins/*metabolism
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - RNA-Binding Proteins/*metabolism
EDAT- 2011/09/29 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Jun;25(12):539-41.