PMID- 21951387
OWN - NLM
STAT- MEDLINE
DCOM- 20120614
LR  - 20120306
IS  - 1463-1326 (Electronic)
IS  - 1462-8902 (Linking)
VI  - 14
IP  - 4
DP  - 2012 Apr
TI  - Current evidence for a role of GLP-1 in Roux-en-Y gastric bypass-induced 
      remission of type 2 diabetes.
PG  - 291-8
LID - 10.1111/j.1463-1326.2011.01505.x [doi]
AB  - Weight-reducing surgical procedures such as Roux-en-Y gastric bypass (RYGB) have 
      proven efficient as means of decreasing excess body weight. Furthermore, some 
      studies report that up to 80% of patients with type 2 diabetes mellitus (T2DM) 
      undergoing RYGB experience complete remission of their T2DM. Interestingly, the 
      majority of remissions occur almost immediately following the operation and long 
      before significant weight loss has taken place. Following RYGB, dramatic 
      increases in postprandial plasma concentrations of the incretin hormone 
      glucagon-like peptide-1 (GLP-1) have been recorded, and the known antidiabetic 
      effects of GLP-1 are thought to be key mediators in RYGB-induced remission of 
      T2DM. However, the published studies on the impact of RYGB on GLP-1 secretion are 
      few, small and often not controlled properly. Furthermore, mechanistic studies 
      delineating the role of endogenous GLP-1 secretion in RYGB-induced remission of 
      T2DM are lacking. This article critically evaluates the current evidence for a 
      role of GLP-1 in RYGB-induced remission of T2DM.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Rhee, N A
AU  - Rhee NA
AD  - Diabetes Research Division, Department of Internal Medicine F, Gentofte Hospital, 
      University of Copenhagen, Niels Andersens Vej 65, Hellerup, Denmark.
FAU - Vilsboll, T
AU  - Vilsboll T
FAU - Knop, F K
AU  - Knop FK
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111113
PL  - England
TA  - Diabetes Obes Metab
JT  - Diabetes, obesity & metabolism
JID - 100883645
RN  - 0 (Blood Glucose)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
SB  - IM
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/*metabolism/*surgery
MH  - Evidence-Based Medicine
MH  - Female
MH  - *Gastric Bypass/methods
MH  - Glucagon-Like Peptide 1/*metabolism
MH  - Homeostasis
MH  - Humans
MH  - Male
MH  - Obesity/*metabolism/*surgery
MH  - Postoperative Period
MH  - Remission Induction/methods
MH  - Treatment Outcome
MH  - Weight Loss
EDAT- 2011/09/29 06:00
MHDA- 2012/06/15 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/06/15 06:00 [medline]
AID - 10.1111/j.1463-1326.2011.01505.x [doi]
PST - ppublish
SO  - Diabetes Obes Metab. 2012 Apr;14(4):291-8. doi: 10.1111/j.1463-1326.2011.01505.x. 
      Epub 2011 Nov 13.