PMID- 21951768
OWN - NLM
STAT- MEDLINE
DCOM- 20120817
LR  - 20161020
IS  - 1442-2050 (Electronic)
IS  - 1120-8694 (Linking)
VI  - 25
IP  - 3
DP  - 2012 Apr
TI  - Human leukocyte antigen class I on peripheral blood mononuclear cells as a 
      non-invasive biomarker for esophageal cancer.
PG  - 273-8
LID - 10.1111/j.1442-2050.2011.01245.x [doi]
AB  - Esophageal cancer (EC) is a common malignant cancer threatening people's health. 
      There are no universally accepted parameters for its early diagnosis. The aim of 
      this study was to observe the expression of human leukocyte antigen class I 
      (HLA-I) on peripheral blood mononuclear cells (PBMCs) of EC patients and in 
      individuals of high-incidence area of EC so as to evaluate the feasibility of 
      using this parameter as a potential non-invasive biomarker for the early 
      diagnosis of EC. The present study enrolled 58 pathological confirmed EC 
      patients, 46 patients with benign esophageal disease, and 65 healthy volunteers. 
      Expression levels of HLA-I protein and mRNA on PBMCs were determined by flow 
      cytometry and quantitative reverse transcriptase polymerase chain reaction, 
      respectively. Then, 181 volunteers from Lijiadian, a village with high morbidity 
      of EC, and 153 age- and gender-matched health volunteers were involved in this 
      study to observe HLA-I expressions in individuals of high-incidence area of EC. 
      Compared with benign esophageal disease and health volunteers, the expressions of 
      HLA-I protein and mRNA on PBMCs of EC patients are significantly decreased, 
      especially in patients with stage III and IV EC, but was not influenced by 
      patient's age and gender. Furthermore, individuals of high-incidence area of EC 
      also show downregulated HLA-I protein, but not mRNA, expression on PBMCs. 
      Altogether, HLA-I expression on PBMCs of EC patients and individuals from 
      high-incidence area of EC is downregulated, and this parameter might be used as a 
      potential predictor of EC.
CI  - (c) 2011 Copyright the Authors. Journal compilation (c) 2011, Wiley Periodicals, Inc. 
      and the International Society for Diseases of the Esophagus.
FAU - Zhang, Z
AU  - Zhang Z
AD  - Department of Health Examination Center, Qilu Hospital, Shandong University, 
      Jinan, China. zhangzhimian@126.com
FAU - Li, Y
AU  - Li Y
FAU - Guan, X
AU  - Guan X
FAU - Yang, X
AU  - Yang X
FAU - Yang, X
AU  - Yang X
FAU - Li, S
AU  - Li S
FAU - Zou, X
AU  - Zou X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110923
PL  - United States
TA  - Dis Esophagus
JT  - Diseases of the esophagus : official journal of the International Society for 
      Diseases of the Esophagus
JID - 8809160
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*blood
MH  - Carcinoma, Squamous Cell/*blood/genetics/*pathology
MH  - China
MH  - Down-Regulation
MH  - Esophageal Neoplasms/*blood/genetics/*pathology
MH  - Female
MH  - Histocompatibility Antigens Class I/*metabolism
MH  - Humans
MH  - Leukocytes, Mononuclear/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - RNA, Messenger/metabolism
EDAT- 2011/09/29 06:00
MHDA- 2012/08/18 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/08/18 06:00 [medline]
AID - 10.1111/j.1442-2050.2011.01245.x [doi]
PST - ppublish
SO  - Dis Esophagus. 2012 Apr;25(3):273-8. doi: 10.1111/j.1442-2050.2011.01245.x. Epub 
      2011 Sep 23.