PMID- 21951954 OWN - NLM STAT- MEDLINE DCOM- 20120306 LR - 20161125 IS - 1479-8301 (Electronic) IS - 1346-3500 (Linking) VI - 11 IP - 3 DP - 2011 Sep TI - Association between brain-derived neurotrophic factor (BDNF) gene polymorphisms and executive function in Japanese patients with Alzheimer's disease. PG - 141-9 LID - 10.1111/j.1479-8301.2011.00364.x [doi] AB - BACKGROUND: To address the functional roles of genetic polymorphisms of brain-derived neurotrophic factor (BDNF) in Alzheimer's disease (AD) from a neuropsychological aspect, we used a cross-sectional study design to investigate the association between novel single nucleotide polymorphisms (SNPs) of the BDNF gene (Val66Met (G196A) and C270T) and the Frontal Assessment Battery (FAB) score, which reflects executive function as a non-memory cognitive impairment. METHODS: One hundred and sixty-nine outpatients with AD or amnestic mild cognitive impairment (A-MCI) were recruited to the study and divided into three genotypic groups for each representative BDNF functional polymorphism as follows: (i) Val66Met (G196A): G/G (n = 45), G/A (n = 104), and A/A (n = 20); and (ii) C270T: C/C (n = 160), C/T (n = 9), and T/T (n = 0). Then, age, sex ratio, duration of illness (months), education years, Mini-Mental State Examination (MMSE) score, behavioral pathology in Alzheimer disease (Behave-AD) score, Clinical Dementia Rating (CDR) ratio, and total and subtest FAB scores were compared between the genotypic groups for each SNP. RESULTS: Significant differences were found in the total (P < 0.01) and subtest (conflicting instructions and prehension behavior; P < 0.01) FAB scores between the C270T polymorphism groups (C/C and C/T), but not among the G196A polymorphism groups. However, no significant differences in age, sex ratio, duration of illness (months), education years, Behave-AD score, CDR ratio, or MMSE score (reflecting attention and memory function) were found between the individual polymorphism genotypes (G196A and C270T). CONCLUSION: Of the known BDNF polymorphisms, the C270T SNP may influence executive dysfunction as a non-memory cognitive impairment in Japanese patients with AD. CI - (c) 2011 The Authors. Psychogeriatrics (c) 2011 Japanese Psychogeriatric Society. FAU - Nagata, Tomoyuki AU - Nagata T AD - Division of Molecular Genetics, Institute of DNA Medicine, Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan. t.nagata@jikei.ac.jp FAU - Shinagawa, Shunichiro AU - Shinagawa S FAU - Nukariya, Kazutaka AU - Nukariya K FAU - Ochiai, Yusuke AU - Ochiai Y FAU - Kawamura, Satoshi AU - Kawamura S FAU - Agawa-Ohta, Miyuki AU - Agawa-Ohta M FAU - Kasahara, Hiroo AU - Kasahara H FAU - Nakayama, Kazuhiko AU - Nakayama K FAU - Yamada, Hisashi AU - Yamada H LA - eng PT - Journal Article DEP - 20110615 PL - England TA - Psychogeriatrics JT - Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society JID - 101230058 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Age Factors MH - Aged MH - Aged, 80 and over MH - *Alleles MH - Alzheimer Disease/diagnosis/*genetics MH - Brain-Derived Neurotrophic Factor/*genetics MH - Cognitive Dysfunction/diagnosis/*genetics MH - Disease Progression MH - *Executive Function MH - Female MH - Genotype MH - Humans MH - Japan MH - Male MH - Mental Status Schedule/statistics & numerical data MH - Neuropsychological Tests/statistics & numerical data MH - Polymorphism, Genetic/*genetics MH - Polymorphism, Single Nucleotide/genetics MH - Psychometrics MH - Risk Factors MH - Sex Factors MH - Statistics as Topic EDAT- 2011/09/29 06:00 MHDA- 2012/03/07 06:00 CRDT- 2011/09/29 06:00 PHST- 2011/09/29 06:00 [entrez] PHST- 2011/09/29 06:00 [pubmed] PHST- 2012/03/07 06:00 [medline] AID - 10.1111/j.1479-8301.2011.00364.x [doi] PST - ppublish SO - Psychogeriatrics. 2011 Sep;11(3):141-9. doi: 10.1111/j.1479-8301.2011.00364.x. Epub 2011 Jun 15.