PMID- 21952284
OWN - NLM
STAT- MEDLINE
DCOM- 20120328
LR  - 20120426
IS  - 1540-336X (Electronic)
IS  - 1528-9117 (Linking)
VI  - 17
IP  - 5
DP  - 2011 Sep-Oct
TI  - Dendritic cells: indispensable?
PG  - 337-42
LID - 10.1097/PPO.0b013e3182350077 [doi]
AB  - Dendritic cells (DCs) control the initiation and differentiation of T cells. In 
      the steady state, DCs mediate tolerance. To achieve immunization, the tolerogenic 
      function of DCs must be switched off by inducing their maturation with 
      appropriate "adjuvants." Dendritic cells form a system composed of distinct 
      subsets that differ in their expression of endocytic and signaling receptors. 
      These subsets have different capacities to differentiate and polarize T cells and 
      to cross-present antigen to expand CD8+ T cells. Optimization of vaccines is 
      possible by exploiting the unique biological properties of DCs.
FAU - Schuler, Gerold
AU  - Schuler G
AD  - Department of Dermatology, University Hospital Erlangen, Germany. 
      gerold.schuler@uk-erlangen.de
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cancer J
JT  - Cancer journal (Sudbury, Mass.)
JID - 100931981
RN  - 0 (Vaccines)
SB  - IM
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Dendritic Cells/*immunology
MH  - Drug Design
MH  - Humans
MH  - T-Lymphocytes/*immunology
MH  - Vaccination/methods
MH  - Vaccines/*immunology
EDAT- 2011/09/29 06:00
MHDA- 2012/03/29 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/03/29 06:00 [medline]
AID - 00130404-201109000-00012 [pii]
AID - 10.1097/PPO.0b013e3182350077 [doi]
PST - ppublish
SO  - Cancer J. 2011 Sep-Oct;17(5):337-42. doi: 10.1097/PPO.0b013e3182350077.