PMID- 21952357
OWN - NLM
STAT- MEDLINE
DCOM- 20120124
LR  - 20151119
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 145
IP  - 6
DP  - 2011 Dec
TI  - Effect of silymarin in the treatment of allergic rhinitis.
PG  - 904-9
LID - 10.1177/0194599811423504 [doi]
AB  - OBJECTIVE: Although the role of oxidative stresses has been confirmed in the 
      pathophysiology of allergic rhinitis and the protective effect of silymarin 
      against oxidative stresses has been proven in different organs, no study has yet 
      been conducted on the impact of silymarin on allergic rhinitis treatment. STUDY 
      DESIGN: A randomized clinical trial study. SETTING: Two tertiary referral centers 
      with otorhinolaryngology-head and neck surgery and allergy and immunology 
      departments. PATIENTS AND METHODS: In a randomized clinical trial, 94 patients 
      with the signs and symptoms of allergic rhinitis and a positive skin prick test 
      were selected and randomly divided into 2 groups. Their signs and symptoms, 
      eosinophil percentage on nasal smear, serum IgE, and interleukin (IL-4, IL-5, 
      interferon-gamma) levels were recorded. The study group was treated with silymarin, 
      whereas the control group received placebo, both for 1 month, along with routine 
      antihistamine treatment. At the end of the treatment course, clinical and 
      laboratory findings were statistically analyzed. RESULTS: Sixty patients 
      completed the trial. Based on the Sino-Nasal Outcome Test 20 (SNOT-20), a 
      significant improvement in clinical symptom severity was observed in both groups 
      (9.23 +/- 5.14 vs 2.20 +/- 2.69; P < .001), which was statistically significantly 
      higher in the study group (P < .001). Posttreatment percentage of nasal 
      eosinophils and cytokine levels showed no significant difference (P > .05). Rise 
      in serum IgE level was seen after treatment with silymarin (P = .003). 
      CONCLUSION: Considering the statistically effective role of silymarin in 
      alleviating the severity of allergic rhinitis symptoms, applying this herbal 
      antioxidant along with other medications may result in better management.
FAU - Bakhshaee, Mehdi
AU  - Bakhshaee M
AD  - Ear, Nose and Throat Research Center, Imam Reza Hospital, Faculty of Medicine, 
      Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Jabbari, Farahzad
AU  - Jabbari F
FAU - Hoseini, Saeed
AU  - Hoseini S
FAU - Farid, Reza
AU  - Farid R
FAU - Sadeghian, Mohammad Hadi
AU  - Sadeghian MH
FAU - Rajati, Mohsen
AU  - Rajati M
FAU - Mohamadpoor, Amir Houshang
AU  - Mohamadpoor AH
FAU - Movahhed, Rahman
AU  - Movahhed R
FAU - Zamani, Mohammad Ali
AU  - Zamani MA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110927
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
RN  - 0 (Allergens)
RN  - 0 (Antioxidants)
RN  - 0 (Cytokines)
RN  - 0 (Interleukins)
RN  - 0 (Silymarin)
SB  - IM
MH  - Adult
MH  - Allergens
MH  - Antioxidants/*administration & dosage
MH  - Cytokines/blood
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Drug Administration Schedule
MH  - Eosinophils/immunology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Interleukins/blood
MH  - Male
MH  - Prospective Studies
MH  - Reference Values
MH  - Rhinitis, Allergic, Seasonal/*diagnosis/*drug therapy/immunology
MH  - Severity of Illness Index
MH  - Silymarin/*therapeutic use
MH  - Skin Tests/methods
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/09/29 06:00
MHDA- 2012/01/25 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/01/25 06:00 [medline]
AID - 0194599811423504 [pii]
AID - 10.1177/0194599811423504 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2011 Dec;145(6):904-9. doi: 10.1177/0194599811423504. 
      Epub 2011 Sep 27.