PMID- 21952423
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20221207
IS  - 1663-2826 (Electronic)
IS  - 1663-2818 (Linking)
VI  - 76
IP  - 5
DP  - 2011
TI  - Association of HLA alleles with autoimmune thyroid disease in Korean children.
PG  - 328-34
LID - 10.1159/000331134 [doi]
AB  - BACKGROUNDS: Data regarding genetics of Hashimoto's disease (HD) and Graves' 
      disease (GD) in Korean children are lacking. METHODS: 73 patients with autoimmune 
      thyroid disease (AITD; HD 32, GD 41) were recruited. We analyzed human leukocyte 
      antigen (HLA) class I and HLA-DRB1 by PCR-SSP, and compared them with those of 
      159 controls. RESULTS: In AITD, the allele frequencies of HLA-A*02, -B*46, -Cw*01 
      and -DRB1*08 were higher and those of HLA-A*30, -B*07, -Cw*07 and -DRB1*01 were 
      lower than in controls. In HD, those of HLA-B*46 and -Cw*01 were higher and those 
      of HLA-DRB1*01 and -Cw*07 were lower than in controls. In GD, those of HLA-A*02, 
      -B*46, -Cw*01 and -DRB1*08 were higher and those of HLA-DRB1*07 and -Cw*07 were 
      lower than in controls. Between HD and GD, there were no significant differences 
      in allele frequencies. The risk of AITD in the presence of both HLA-B*46 and 
      -Cw*01 is higher than in the presence of either allele alone. CONCLUSION: The 
      susceptible and protectable alleles in HD are similar to those in GD. Coexistence 
      of HLA-B*46 and -Cw*01 may be a genetic gene marker for early-onset AITD in 
      Koreans.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Cho, Won Kyoung
AU  - Cho WK
AD  - Department of Pediatrics, College of Medicine, The Catholic University of Korea, 
      Seoul, Korea.
FAU - Jung, Min Ho
AU  - Jung MH
FAU - Choi, Eun-Jeong
AU  - Choi EJ
FAU - Choi, Hee-Baeg
AU  - Choi HB
FAU - Kim, Tai-Gyu
AU  - Kim TG
FAU - Suh, Byung-Kyu
AU  - Suh BK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110927
PL  - Switzerland
TA  - Horm Res Paediatr
JT  - Hormone research in paediatrics
JID - 101525157
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Asian People/*genetics
MH  - Autoimmune Diseases/genetics
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - Hashimoto Disease/ethnology/genetics
MH  - Humans
MH  - Male
MH  - Thyroiditis, Autoimmune/ethnology/*genetics
EDAT- 2011/09/29 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/02/11 00:00 [received]
PHST- 2011/07/22 00:00 [accepted]
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 000331134 [pii]
AID - 10.1159/000331134 [doi]
PST - ppublish
SO  - Horm Res Paediatr. 2011;76(5):328-34. doi: 10.1159/000331134. Epub 2011 Sep 27.