PMID- 21953406
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20130520
IS  - 1527-3350 (Electronic)
IS  - 0270-9139 (Linking)
VI  - 55
IP  - 2
DP  - 2012 Feb
TI  - Human leukocyte antigen class II molecules confer both susceptibility and 
      progression in Japanese patients with primary biliary cirrhosis.
PG  - 506-11
LID - 10.1002/hep.24705 [doi]
AB  - Along with twin and family studies, recent genome-wide association studies 
      suggest that genetic factors contribute to the susceptibility and severity of 
      primary biliary cirrhosis (PBC). Although several reports have demonstrated that 
      the human leukocyte antigen (HLA) DRB1*08:03 allele is associated with disease 
      susceptibility in Japan, the precise analysis of HLA haplotypes and the role of 
      amino acid alignment have not been fully clarified. We investigated HLA class I 
      A, B, and C and HLA class II DRB1 and DQB1 alleles and haplotypes in 229 Japanese 
      patients with PBC and compared them with the published data of 523 healthy 
      subjects. Significant associations were found with PBC susceptibility for the 
      DRB1*08:03-DQB1*06:01 (13% versus 6%; P = 0.000025; odds ratio [OR] = 2.22) and 
      DRB1*04:05-DQB1*04:01 haplotypes (17% versus 13%; P = 0.044; OR = 1.38). 
      Conversely, there were significant protective associations with the 
      DRB1*13:02-DQB1*06:04 (2% versus 5%; P = 0.00093; OR = 0.27) and 
      DRB1*11:01-DQB1*03:01 haplotypes (1% versus 4%; P = 0.03; OR = 0.37). The 
      frequency of the DRB1*09:01-DQB1*03:03 haplotype was significantly higher in 
      patients who had received orthotopic liver transplantation (33% versus 11%; P = 
      0.0012; OR = 3.96). Furthermore, the frequency of serine at position 57 (P = 
      0.0000015; OR = 1.83) of the DRbetachain differed the most in patients with PBC, 
      compared with healthy subjects. CONCLUSION: This study established the role of 
      HLA haplotypes in determining PBC susceptibility and progression in the Japanese 
      population. Further resequencing of the HLA region is required to more precisely 
      identify the genetic components of PBC.
CI  - Copyright (c) 2011 American Association for the Study of Liver Diseases.
FAU - Umemura, Takeji
AU  - Umemura T
AD  - Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu 
      University School of Medicine, Matsumoto, Japan. tumemura@shinshu-u.ac.jp
FAU - Joshita, Satoru
AU  - Joshita S
FAU - Ichijo, Tetsuya
AU  - Ichijo T
FAU - Yoshizawa, Kaname
AU  - Yoshizawa K
FAU - Katsuyama, Yoshihiko
AU  - Katsuyama Y
FAU - Tanaka, Eiji
AU  - Tanaka E
FAU - Ota, Masao
AU  - Ota M
CN  - Shinshu PBC Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111219
PL  - United States
TA  - Hepatology
JT  - Hepatology (Baltimore, Md.)
JID - 8302946
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Case-Control Studies
MH  - Disease Progression
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Liver Cirrhosis, Biliary/genetics/*immunology
MH  - Male
MH  - Middle Aged
FIR - Ichikawa-Yamada, Yuki
IR  - Ichikawa-Yamada Y
FIR - Kimura, Takefumi
IR  - Kimura T
FIR - Morita, Susumu
IR  - Morita S
FIR - Kamijo, Atsushi
IR  - Kamijo A
FIR - Komatsu, Michiharu
IR  - Komatsu M
FIR - Matsumoto, Akihiro
IR  - Matsumoto A
FIR - Yamamura, Nobuyoshi
IR  - Yamamura N
EDAT- 2011/09/29 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/19 00:00 [accepted]
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 10.1002/hep.24705 [doi]
PST - ppublish
SO  - Hepatology. 2012 Feb;55(2):506-11. doi: 10.1002/hep.24705. Epub 2011 Dec 19.