PMID- 21953485
OWN - NLM
STAT- MEDLINE
DCOM- 20120316
LR  - 20220321
IS  - 1613-2246 (Electronic)
IS  - 0021-5155 (Linking)
VI  - 55
IP  - 6
DP  - 2011 Nov
TI  - Incidence of deepening of the upper eyelid sulcus after switching from 
      latanoprost to bimatoprost.
PG  - 600-4
LID - 10.1007/s10384-011-0075-6 [doi]
AB  - PURPOSE: To investigate the incidence of deepening of the upper eyelid sulcus 
      (DUES) after use of bimatoprost in Japanese glaucoma patients. METHODS: 
      Twenty-five open-angle glaucoma Japanese patients treated with latanoprost in 
      both eyes for 6 months or longer and needing further intraocular pressure (IOP) 
      reduction were enrolled prospectively. Latanoprost was switched to bimatoprost, 
      and the patients were observed at 1, 3, and 6 months. The patients were queried 
      for the presence of DUES at every visit. Sex, refraction, and IOP were evaluated 
      as related factors. The photographs of the eyes and forehead taken at each of the 
      four visits were randomly displayed and judged for the presence of DUES with 
      unanimous confirmation by three examiners. RESULTS: One month after the switch to 
      bimatoprost, 44% (11/25) of the patients had DUES, including three with 
      unilateral DUES. At 3 and 6 months, 60% (15/25) of the patients had DUES. The 
      incidence was significantly higher in older patients and nonmyopic eyes (P < 
      0.01), but not related to sex or IOP reduction. Finally, 53.3% (8/15) of the 
      patients objectively judged to have DUES noticed the presence of DUES by 
      themselves. Only one patient dropped out of the study because of DUES (after 3 
      months). CONCLUSION: DUES is an often-observed side effect of bimatoprost topical 
      treatment in Japanese glaucoma patients.
FAU - Aihara, Makoto
AU  - Aihara M
AD  - Department of Ophthalmology, University of Tokyo School of Medicine, 7-3-1 Hongo, 
      Bunkyo-ku, Tokyo, 113-8655, Japan. aihara-tky@umin.ac.jp
FAU - Shirato, Shiroaki
AU  - Shirato S
FAU - Sakata, Rei
AU  - Sakata R
LA  - eng
PT  - Journal Article
DEP - 20110928
PL  - Japan
TA  - Jpn J Ophthalmol
JT  - Japanese journal of ophthalmology
JID - 0044652
RN  - 0 (Amides)
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Prostaglandins F, Synthetic)
RN  - 4208238832 (Cloprostenol)
RN  - 6Z5B6HVF6O (Latanoprost)
RN  - QXS94885MZ (Bimatoprost)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amides/*adverse effects
MH  - Antihypertensive Agents/*adverse effects/therapeutic use
MH  - Bimatoprost
MH  - Cloprostenol/adverse effects/*analogs & derivatives
MH  - Drug Substitution
MH  - Eyelid Diseases/*chemically induced
MH  - Female
MH  - Glaucoma, Open-Angle/*drug therapy
MH  - Humans
MH  - Incidence
MH  - Intraocular Pressure/drug effects
MH  - Latanoprost
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Prostaglandins F, Synthetic/*therapeutic use
EDAT- 2011/09/29 06:00
MHDA- 2012/03/17 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/02/13 00:00 [received]
PHST- 2011/06/22 00:00 [accepted]
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/03/17 06:00 [medline]
AID - 10.1007/s10384-011-0075-6 [doi]
PST - ppublish
SO  - Jpn J Ophthalmol. 2011 Nov;55(6):600-4. doi: 10.1007/s10384-011-0075-6. Epub 2011 
      Sep 28.