PMID- 21955305
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20131121
IS  - 1369-1600 (Electronic)
IS  - 1355-6215 (Linking)
VI  - 18
IP  - 3
DP  - 2013 May
TI  - Self-administered MDMA produces dose- and time-dependent serotonin deficits in 
      the rat brain.
PG  - 441-7
LID - 10.1111/j.1369-1600.2011.00370.x [doi]
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) use and abuse have been increasing 
      worldwide. Of concern, exposure to high doses of MDMA decreases several markers 
      of serotonin (5HT) neurotransmission and produces deficits in tissue levels of 
      5HT. Studies in laboratory animals have been conducted primarily following large 
      doses (20.0-80.0 mg/kg) of experimenter-administered MDMA, but it is unclear 
      whether similar persistent deficits in tissue 5HT levels are produced following 
      self-administration. In this study, tissue levels of 5HT in the frontal cortex, 
      striatum and hippocampus were measured following different levels of 
      self-administered MDMA. For both groups, responding was initially reinforced by 
      an infusion of 1.0 mg/kg/infusion MDMA. The dose was reduced to 
      0.5 mg/kg/infusion once 90 infusions had been self-administered. For the two 
      groups, testing continued until either a total of 165 or 315 mg/kg had been 
      self-administered. Assays were conducted either 2 or 10 weeks following the last 
      self-administration session. The lower dose exposure regimen failed to 
      significantly decrease 5HT levels in any brain region. The higher dose exposure, 
      however, decreased 5HT levels by 30-35% in all three brain regions 2 weeks, but 
      not 10 weeks, following self-administration. Thus, MDMA self-administration 
      produced dose- and time-dependent deficits in tissue levels of 5HT, suggesting 
      that similar deficits would be produced in humans who use and abuse the drug.
CI  - (c) 2011 The Authors, Addiction Biology (c) 2011 Society for the Study of Addiction.
FAU - Do, Jennifer
AU  - Do J
AD  - Victoria University of Wellington, School of Psychology, New Zealand.
FAU - Schenk, Susan
AU  - Schenk S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110928
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
RN  - 0 (Serotonin Agents)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adaptation, Physiological/drug effects
MH  - Analysis of Variance
MH  - Animals
MH  - Brain/*drug effects/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Infusions, Intravenous
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Self Administration
MH  - Serotonin/*metabolism
MH  - Serotonin Agents/administration & dosage/*pharmacology
EDAT- 2011/10/01 06:00
MHDA- 2013/10/18 06:00
CRDT- 2011/09/30 06:00
PHST- 2011/09/30 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - 10.1111/j.1369-1600.2011.00370.x [doi]
PST - ppublish
SO  - Addict Biol. 2013 May;18(3):441-7. doi: 10.1111/j.1369-1600.2011.00370.x. Epub 
      2011 Sep 28.