PMID- 21956423
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20220309
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 96
IP  - 12
DP  - 2011 Dec
TI  - Circulating concentrations of monocyte chemoattractant protein-1, plasminogen 
      activator inhibitor-1, and soluble leukocyte adhesion molecule-1 in 
      overweight/obese men and women consuming fructose- or glucose-sweetened beverages 
      for 10 weeks.
PG  - E2034-8
LID - 10.1210/jc.2011-1050 [doi]
AB  - CONTEXT: Results from animal studies suggest that consumption of large amounts of 
      fructose can promote inflammation and impair fibrinolysis. Data describing the 
      effects of fructose consumption on circulating levels of proinflammatory and 
      prothrombotic markers in humans are unavailable. OBJECTIVE: Our objective was to 
      determine the effects of 10 wk of dietary fructose or glucose consumption on 
      plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), plasminogen 
      activator inhibitor-1 (PAI-1), E-selectin, intercellular adhesion molecule-1, 
      C-reactive protein, and IL-6. DESIGN AND SETTING: This was a parallel-arm study 
      with two inpatient phases (2 wk baseline, final 2 wk intervention), conducted in 
      a clinical research facility, and an outpatient phase (8 wk) during which 
      subjects resided at home. PARTICIPANTS: Participants were older (40-72 yr), 
      overweight/obese (body mass index = 25-35 kg/m(2)) men (n = 16) and women (n = 
      15). INTERVENTIONS: Participants consumed glucose- or fructose-sweetened 
      beverages providing 25% of energy requirements for 10 wk. Blood samples were 
      collected at baseline and during the 10th week of intervention. MAIN OUTCOME 
      MEASURES: Fasting concentrations of MCP-1 (P = 0.009), PAI-1 (P = 0.002), and 
      E-selectin (P = 0.048) as well as postprandial concentrations of PAI-1 (P < 
      0.0001) increased in subjects consuming fructose but not in those consuming 
      glucose. Fasting levels of C-reactive protein, IL-6, and intercellular adhesion 
      molecule-1 were not changed in either group. CONCLUSIONS: Consumption of fructose 
      for 10 wk leads to increases of MCP-1, PAI-1, and E-selectin. These findings 
      suggest the possibility that fructose may contribute to the development of the 
      metabolic syndrome via effects on proinflammatory and prothrombotic mediators.
FAU - Cox, Chad L
AU  - Cox CL
AD  - Department of Molecular Biosciences, School of Veterinary Medicine, University of 
      California, Davis, One Shields Avenue, Davis, California 95616, USA.
FAU - Stanhope, Kimber L
AU  - Stanhope KL
FAU - Schwarz, Jean Marc
AU  - Schwarz JM
FAU - Graham, James L
AU  - Graham JL
FAU - Hatcher, Bonnie
AU  - Hatcher B
FAU - Griffen, Steven C
AU  - Griffen SC
FAU - Bremer, Andrew A
AU  - Bremer AA
FAU - Berglund, Lars
AU  - Berglund L
FAU - McGahan, John P
AU  - McGahan JP
FAU - Keim, Nancy L
AU  - Keim NL
FAU - Havel, Peter J
AU  - Havel PJ
LA  - eng
SI  - ClinicalTrials.gov/NCT01165853
GR  - HL-091333/HL/NHLBI NIH HHS/United States
GR  - K23 DK097307/DK/NIDDK NIH HHS/United States
GR  - AT-003545/AT/NCCIH NIH HHS/United States
GR  - UL1 RR024146/RR/NCRR NIH HHS/United States
GR  - R01 HL075675/HL/NHLBI NIH HHS/United States
GR  - R01 HL091333/HL/NHLBI NIH HHS/United States
GR  - R01 HL-075675/HL/NHLBI NIH HHS/United States
GR  - DK-097307/DK/NIDDK NIH HHS/United States
GR  - R01 HL107256/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20110928
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Blood Glucose)
RN  - 0 (Chemokine CCL2)
RN  - 0 (E-Selectin)
RN  - 0 (Plasminogen Activator Inhibitor 1)
RN  - 0 (Sweetening Agents)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 126880-86-2 (L-Selectin)
RN  - 30237-26-4 (Fructose)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Beverages
MH  - Blood Glucose/metabolism
MH  - C-Reactive Protein/metabolism
MH  - Chemokine CCL2/*blood
MH  - E-Selectin/blood
MH  - Female
MH  - Fructose/*administration & dosage
MH  - Glucose/*administration & dosage
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/blood
MH  - L-Selectin/*blood
MH  - Male
MH  - Middle Aged
MH  - Obesity/*blood
MH  - Overweight/*blood
MH  - Plasminogen Activator Inhibitor 1/*blood
MH  - Postprandial Period/drug effects/physiology
MH  - Sweetening Agents/administration & dosage
PMC - PMC3232623
EDAT- 2011/10/01 06:00
MHDA- 2012/02/10 06:00
PMCR- 2012/12/01
CRDT- 2011/09/30 06:00
PHST- 2011/09/30 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
PHST- 2012/12/01 00:00 [pmc-release]
AID - jc.2011-1050 [pii]
AID - 11-1050 [pii]
AID - 10.1210/jc.2011-1050 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2011 Dec;96(12):E2034-8. doi: 10.1210/jc.2011-1050. Epub 
      2011 Sep 28.