PMID- 21956681
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20220223
IS  - 1097-0045 (Electronic)
IS  - 0270-4137 (Linking)
VI  - 72
IP  - 8
DP  - 2012 Jun 1
TI  - Y chromosome losses are exceedingly rare in prostate cancer and unrelated to 
      patient age.
PG  - 898-903
LID - 10.1002/pros.21492 [doi]
AB  - BACKGROUND: Loss of the Y chromosome is a frequently reported chromosomal 
      abnormality in many tumor types. This study was undertaken to investigate the 
      frequency of Y chromosome losses and this chromosomal abnormality might play a 
      potential role in prostate cancer. METHODS: A preexisting prostate cancer tissue 
      microarray (TMA) containing samples of 3,261 patients treated by radical 
      prostatectomy with clinical follow-up data was used in this study. TMA sections 
      were analyzed by fluorescence in situ hybridization (FISH) using a dual labeling 
      probe for the centromeres of the X and Y chromosome. RESULTS: Unequivocal losses 
      of the Y chromosome were seen in only 12 of 2,053 analyzable cases. No 
      significant associations were found between Y loss and patient age, pT stage, and 
      the risk of PSA recurrence. Interestingly, in our study the presence of Y losses 
      was significantly associated with high Gleason grade (P = 0.0034). CONCLUSIONS: 
      Loss of the Y chromosome is a rare event in prostate cancer. Y losses occur in 
      much higher rates in most other cancer types. For this reason, we suggest that 
      the expression of at least one Y chromosome gene is essential for prostate 
      epithelial cells and it is possible that such a gene could represent a suitable 
      target for future therapy of prostate cancer.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Stahl, Phillip R
AU  - Stahl PR
AD  - Institute of Pathology, University Medical Center Hamburg-Eppendorf, 
      Martinistrasse 52,20246 Hamburg, Germany. p.stahl@uke.de
FAU - Kilgue, Adisa
AU  - Kilgue A
FAU - Tennstedt, Pierre
AU  - Tennstedt P
FAU - Minner, Sarah
AU  - Minner S
FAU - Krohn, Antje
AU  - Krohn A
FAU - Simon, Ronald
AU  - Simon R
FAU - Krause, Geeske V
AU  - Krause GV
FAU - Izbicki, Jakob
AU  - Izbicki J
FAU - Graefen, Markus
AU  - Graefen M
FAU - Sauter, Guido
AU  - Sauter G
FAU - Schlomm, Thorsten
AU  - Schlomm T
FAU - Wilczak, Waldemar
AU  - Wilczak W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110928
PL  - United States
TA  - Prostate
JT  - The Prostate
JID - 8101368
SB  - IM
MH  - Aged
MH  - Aging/*genetics/pathology
MH  - Centromere/pathology
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Y
MH  - Follow-Up Studies
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prostatectomy
MH  - Prostatic Neoplasms/*genetics/pathology/surgery
MH  - Retrospective Studies
EDAT- 2011/10/01 06:00
MHDA- 2012/06/27 06:00
CRDT- 2011/09/30 06:00
PHST- 2011/06/15 00:00 [received]
PHST- 2011/09/01 00:00 [accepted]
PHST- 2011/09/30 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
AID - 10.1002/pros.21492 [doi]
PST - ppublish
SO  - Prostate. 2012 Jun 1;72(8):898-903. doi: 10.1002/pros.21492. Epub 2011 Sep 28.