PMID- 21959873
OWN - NLM
STAT- MEDLINE
DCOM- 20120510
LR  - 20161125
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 35
IP  - 2
DP  - 2012 Feb
TI  - T2-weighted cardiac MR assessment of the myocardial area-at-risk and salvage area 
      in acute reperfused myocardial infarction: comparison of state-of-the-art dark 
      blood and bright blood T2-weighted sequences.
PG  - 328-39
LID - 10.1002/jmri.22813 [doi]
AB  - PURPOSE: To compare different state-of-the-art T2-weighted (T2w) imaging 
      sequences combined with late gadolinium enhancement (LGE) for myocardial salvage 
      area (MSA) assessment by cardiac magnetic resonance (CMR). T2w imaging has been 
      used to assess the myocardial area at risk (AAR) in acute myocardial infarction 
      (AMI) patients, but its clinical application is challenging due to technical and 
      physical limitations. MATERIALS AND METHODS: Thirty patients with reperfused AMI 
      underwent complete CMR imaging 2-5 days after hospital admission. Myocardial AAR 
      and MSA were quantified on four different T2w sequences: (a) free-breathing 
      T2-prepared single-shot balanced steady-state free precession (T2p_ssbSSFP); (b) 
      breathhold T2-weighted acquisition for cardiac unified T2 edema (ACUTE); (c) 
      breathhold T2w dark-blood inversion recovery turbo-spin echo (IR-TSE) (short-term 
      inversion recovery: STIR); and (d) free-breathing high-resolution T2 dark-blood 
      navigated BLADE. The diagnostic performance of each technique was also assessed. 
      RESULTS: Quantitative analysis showed significant differences in myocardial AAR 
      extent as quantified by the four T2w sequences (P < 0.05). There were also 
      significant differences in sensitivity, specificity and overall diagnostic 
      performance. CONCLUSION: Detection and quantification of AAR, and thus of MSA, by 
      T2wCMR in reperfused AMI patients varied significantly between different T2w 
      sequences in the same clinical setting.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Viallon, Magalie
AU  - Viallon M
AD  - Department of Radiology, University Hospital of Geneva, Geneva, Switzerland. 
      magalie.viallon@hcuge.ch
FAU - Mewton, Nathan
AU  - Mewton N
FAU - Thuny, Franck
AU  - Thuny F
FAU - Guehring, Jens
AU  - Guehring J
FAU - O'Donnell, Thomas
AU  - O'Donnell T
FAU - Stemmer, Alto
AU  - Stemmer A
FAU - Bi, Xiaoming
AU  - Bi X
FAU - Rapacchi, Stanislas
AU  - Rapacchi S
FAU - Zuehlsdorff, Sven
AU  - Zuehlsdorff S
FAU - Revel, Didier
AU  - Revel D
FAU - Croisille, Pierre
AU  - Croisille P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110929
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 6HG8UB2MUY (Meglumine)
RN  - L0ND3981AG (gadoterate meglumine)
SB  - IM
MH  - Analysis of Variance
MH  - Chi-Square Distribution
MH  - Contrast Media
MH  - Coronary Angiography
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Meglumine
MH  - Middle Aged
MH  - Myocardial Infarction/*pathology/therapy
MH  - Myocardial Reperfusion
MH  - Organometallic Compounds
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Vectorcardiography
EDAT- 2011/10/01 06:00
MHDA- 2012/05/11 06:00
CRDT- 2011/10/01 06:00
PHST- 2010/12/07 00:00 [received]
PHST- 2011/08/12 00:00 [accepted]
PHST- 2011/10/01 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2012/05/11 06:00 [medline]
AID - 10.1002/jmri.22813 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2012 Feb;35(2):328-39. doi: 10.1002/jmri.22813. Epub 2011 
      Sep 29.