PMID- 21962804
OWN - NLM
STAT- MEDLINE
DCOM- 20120106
LR  - 20181201
IS  - 1095-8673 (Electronic)
IS  - 0022-4804 (Linking)
VI  - 171
IP  - 2
DP  - 2011 Dec
TI  - Effects of pioglitazone on survival and omental adipocyte function in mice with 
      sepsis induced by cecal ligation and puncture.
PG  - e215-21
LID - 10.1016/j.jss.2011.08.012 [doi]
AB  - BACKGROUND: To examine the effects of pioglitazone, peroxisome 
      proliferator-activated receptor-gamma (PPAR-gamma), on mortality and omental 
      adipocyte function in mice with cecal ligation and puncture (CLP). METHODS: Male 
      mice were assigned to receive (1) vehicle/sham-operation, (2) pioglitazone/CLP, 
      or (3) vehicle/CLP. Pioglitazone was injected intraperitoneally for 7 d before 
      operation. Serum and omental tissue were collected before, 24, and 48 h after 
      CLP. Serum levels of adiponectin, cytokine, and chemokine were measured with 
      ELISA. mRNA expressions in omental tissues were determined by RT-PCR. Survival 
      was monitored for 7 d after CLP. RESULTS: Survival after CLP was significantly 
      better in the pioglitazone/CLP than in the vehicle/CLP. Serum adiponectin levels 
      before CLP were higher in the pioglitazone/CLP than in the vehicle/CLP. Treatment 
      with pioglitazone significantly inhibited the increases in the serum 
      interleukin-6 and monocyte chemoattractant protein-1 (MCP-1) levels after CLP and 
      lowered the mRNA expressions of proinflammatory cytokines, interleukin-6, and 
      MCP-1 in omental tissue after CLP. CONCLUSION: The anti-inflammatory effects of 
      pioglitazone on omental adipocyte function appear to be mediated in part by 
      PPAR-gamma activation, which down-regulates the production of inflammatory mediators.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Tsujimura, Yukihiro
AU  - Tsujimura Y
AD  - Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life 
      Sciences, Horinouchi, Hachioji, Tokyo, Japan.
FAU - Matsutani, Takeshi
AU  - Matsutani T
FAU - Matsuda, Akihisa
AU  - Matsuda A
FAU - Kutsukake, Masahiko
AU  - Kutsukake M
FAU - Uchida, Eiji
AU  - Uchida E
FAU - Sasajima, Koji
AU  - Sasajima K
FAU - Tamura, Kazuhiro
AU  - Tamura K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110909
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
RN  - 0 (Adiponectin)
RN  - 0 (Adipoq protein, mouse)
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Interleukin-6)
RN  - 0 (Thiazolidinediones)
RN  - X4OV71U42S (Pioglitazone)
SB  - IM
MH  - Adipocytes/*drug effects/physiology
MH  - Adiponectin/blood/genetics
MH  - Animals
MH  - Cecum/*injuries
MH  - Chemokine CCL2/blood/genetics
MH  - Disease Models, Animal
MH  - Gene Expression/immunology
MH  - Hypoglycemic Agents/*pharmacology
MH  - Interleukin-6/blood/genetics
MH  - Ligation
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Omentum/cytology/immunology
MH  - Peritonitis/drug therapy/immunology/mortality
MH  - Pioglitazone
MH  - Sepsis/*drug therapy/immunology/mortality
MH  - Thiazolidinediones/*pharmacology
MH  - Wounds, Stab/immunology
EDAT- 2011/10/04 06:00
MHDA- 2012/01/10 06:00
CRDT- 2011/10/04 06:00
PHST- 2011/04/13 00:00 [received]
PHST- 2011/07/26 00:00 [revised]
PHST- 2011/08/15 00:00 [accepted]
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/04 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
AID - S0022-4804(11)00726-8 [pii]
AID - 10.1016/j.jss.2011.08.012 [doi]
PST - ppublish
SO  - J Surg Res. 2011 Dec;171(2):e215-21. doi: 10.1016/j.jss.2011.08.012. Epub 2011 
      Sep 9.