PMID- 21963561
OWN - NLM
STAT- MEDLINE
DCOM- 20130125
LR  - 20201209
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 138
IP  - 2
DP  - 2011 Nov 18
TI  - Inhibitory effects of Chelidonium majus extract on atopic dermatitis-like skin 
      lesions in NC/Nga mice.
PG  - 398-403
LID - 10.1016/j.jep.2011.09.028 [doi]
AB  - AIM OF THE STUDY: Chelidonium majus (CM) has traditionally been used for 
      treatment of various inflammatory diseases including atopic dermatitis (AD). 
      However its action on atopic dermatitis (AD) is unclear. Therefore, we 
      investigated the effect of CM on AD using NC/Nga mice as an AD model. MATERIALS 
      AND METHODS: The effect of CM on 1-chloro-2,4-dinitrobenzene (DNCB) induced 
      NC/Nga mice was evaluated by examining skin symptom severity, itching behavior, 
      ear thickness, levels of serum immunoglobulin E (IgE), tumor necrosis factor-alpha 
      (TNF-alpha), and interlukin-4 (IL-4), skin histology. RESULTS: The CM significantly 
      reduced the total clinical severity score, itching behavior, ear thickness and 
      the level of serum IgE in AD mouse model. CM not only decreased TNF-alpha but also 
      IL-4. CONCLUSION: These results suggest that CM may be a potential therapeutic 
      modality for AD.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Yang, Gabsik
AU  - Yang G
AD  - Department of Herbology, College of Oriental Medicine, Kyung-Hee University, 
      Seoul 130-701, Republic of Korea.
FAU - Lee, Kyungjin
AU  - Lee K
FAU - Lee, Mi-Hwa
AU  - Lee MH
FAU - Kim, So-Hyung
AU  - Kim SH
FAU - Ham, In-Hye
AU  - Ham IH
FAU - Choi, Ho-Young
AU  - Choi HY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110922
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Dinitrochlorobenzene)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Chelidonium/*chemistry
MH  - Dermatitis, Atopic/*drug therapy
MH  - Dinitrochlorobenzene/toxicity
MH  - Disease Models, Animal
MH  - Immunoglobulin E/blood
MH  - Interleukin-4/blood
MH  - Mice
MH  - Plant Extracts/*therapeutic use
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2011/10/04 06:00
MHDA- 2013/01/26 06:00
CRDT- 2011/10/04 06:00
PHST- 2011/03/24 00:00 [received]
PHST- 2011/08/12 00:00 [revised]
PHST- 2011/09/16 00:00 [accepted]
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/04 06:00 [pubmed]
PHST- 2013/01/26 06:00 [medline]
AID - S0378-8741(11)00698-2 [pii]
AID - 10.1016/j.jep.2011.09.028 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2011 Nov 18;138(2):398-403. doi: 10.1016/j.jep.2011.09.028. 
      Epub 2011 Sep 22.