PMID- 21963669 OWN - NLM STAT- MEDLINE DCOM- 20120405 LR - 20220331 IS - 1873-7811 (Electronic) IS - 0272-7358 (Linking) VI - 31 IP - 8 DP - 2011 Dec TI - The bidirectional relationship of depression and diabetes: a systematic review. PG - 1239-46 LID - 10.1016/j.cpr.2011.08.001 [doi] AB - Depression and diabetes are both serious chronic conditions common in Western cultures. These conditions impart a significant burden on the patients and society. Depression is often comorbid with chronic illness, and past research has found an increased prevalence of depressive symptoms in patients with Type 2 Diabetes Mellitus (T2DM). However, the exact nature and direction of this relationship are unknown. Depression is often thought to be a consequence of diabetes, perhaps due to the burden of chronic illness. Research has also suggested that depression may be a risk factor for development of diabetes, in part due to biochemical changes in depression and in part because of a reduction of health care behaviors in individuals with depression. This paper reviews the literature behind both lines of investigation and includes special diagnostic and clinical considerations for at risk populations. We discuss clinical implications, limitations of current research, and areas of interest for future research. CI - Copyright (c) 2011 Elsevier Ltd. All rights reserved. FAU - Renn, Brenna N AU - Renn BN AD - Department of Psychology, University of Colorado at ColoradoSprings, 1420 Austin Bluffs Parkway, Colorado Springs, CO 80918, USA. FAU - Feliciano, Leilani AU - Feliciano L FAU - Segal, Daniel L AU - Segal DL LA - eng PT - Journal Article PT - Review PT - Systematic Review DEP - 20110824 PL - United States TA - Clin Psychol Rev JT - Clinical psychology review JID - 8111117 SB - IM MH - Chronic Disease MH - Comorbidity MH - Depression/*epidemiology/etiology MH - Diabetes Mellitus, Type 2/complications/*epidemiology MH - Humans MH - Risk Factors EDAT- 2011/10/04 06:00 MHDA- 2012/04/06 06:00 CRDT- 2011/10/04 06:00 PHST- 2011/04/10 00:00 [received] PHST- 2011/08/11 00:00 [revised] PHST- 2011/08/12 00:00 [accepted] PHST- 2011/10/04 06:00 [entrez] PHST- 2011/10/04 06:00 [pubmed] PHST- 2012/04/06 06:00 [medline] AID - S0272-7358(11)00136-X [pii] AID - 10.1016/j.cpr.2011.08.001 [doi] PST - ppublish SO - Clin Psychol Rev. 2011 Dec;31(8):1239-46. doi: 10.1016/j.cpr.2011.08.001. Epub 2011 Aug 24.