PMID- 21964432
OWN - NLM
STAT- MEDLINE
DCOM- 20120402
LR  - 20111125
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 72
IP  - 12
DP  - 2011 Dec
TI  - Major histocompatibility complex and strong human leukocyte antigen-DRB1 and 
      gender association with Vogt-Koyanagi-Harada syndrome in Mexican Mestizos.
PG  - 1198-203
LID - 10.1016/j.humimm.2011.09.002 [doi]
AB  - Vogt-Koyanagi-Harada syndrome (VKH) is a multisystem autoimmune disorder mediated 
      by cytotoxic T cells targeting melanocytes antigen(s). A strong major 
      histocompatibility complex (MHC) association with HLA-DRB1*04:05 has been 
      demonstrated in different populations. We investigated the contribution of 
      HLA-A*, -B*, -C*, -DRB1*, and -DQB1* genes, belonging to the human leukocyte 
      antigen (HLA), to the expression of VKH and we analyzed the influence of gender 
      on the HLA association. A total of 76 patients and 256 healthy Mexican Mestizo 
      individuals were included. HLA-A, B, C, and DQB1 typing was performed using the 
      polymerase chain reaction, and hybridization was done using sequence specific 
      probes. DRB1 alleles were defined by means of sequence base typing. The frequency 
      of DRB1*04:05 (odds ratio=2.95) and DRB1*04:04 (odds ratio=2.79) were found to be 
      significantly increased in the patients, conferring a similar risk. Gender 
      stratification analysis showed that these alleles were associated with female 
      gender only. No HLA class I or class II alleles were significantly deviated in 
      males. The frequency of DRB1*04:07 was increased in the whole group, upon 
      withdrawal from analysis the DRB1*04:04 and *04:05 positive patients. A trend of 
      DRB1 alleles contributing to the expression of VKH is suggested: 
      DRB1*04:05=*04:04>*04:07>*01:01>*01:02. Although none of the results were 
      significant after the p value was corrected, the data are consistent with those 
      in numerous other studies, suggesting that several different DRB1* alleles may be 
      involved in the etiopathogenesis of the disease by presenting an overlapping set 
      of ocular peptides to the T cells, which in turn may trigger the autoimmune 
      response that is present in the patients.
CI  - Copyright (c) 2011. Published by Elsevier Inc.
FAU - Alaez, Carmen
AU  - Alaez C
AD  - Department of Immunology and Immunogenetics, Instituto de Diagnostico y 
      Referencia Epidemiologicas, InDRE, Secretary of Health, Mexico City, Mexico.
FAU - Flores-A, Hilario
AU  - Flores-A H
FAU - Concha del Rio, Luz Elena
AU  - Concha del Rio LE
FAU - Munguia, Andrea
AU  - Munguia A
FAU - Rodriguez, Araceli
AU  - Rodriguez A
FAU - Garcia, David
AU  - Garcia D
FAU - Arellanes, Lourdes
AU  - Arellanes L
FAU - Gorodezky, Clara
AU  - Gorodezky C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110922
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Case-Control Studies
MH  - Child
MH  - Eye/*immunology/pathology
MH  - Female
MH  - Gene Expression
MH  - Gene Frequency
MH  - HLA-A Antigens/genetics/immunology
MH  - HLA-B Antigens/genetics/immunology
MH  - HLA-C Antigens/genetics/immunology
MH  - HLA-DQ Antigens/genetics/immunology
MH  - *HLA-DRB1 Chains/genetics/immunology
MH  - Humans
MH  - Mexico/epidemiology
MH  - Middle Aged
MH  - Sex Factors
MH  - Uveomeningoencephalitic Syndrome/ethnology/genetics/*immunology/pathology
EDAT- 2011/10/04 06:00
MHDA- 2012/04/03 06:00
CRDT- 2011/10/04 06:00
PHST- 2011/02/15 00:00 [received]
PHST- 2011/09/08 00:00 [revised]
PHST- 2011/09/15 00:00 [accepted]
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/04 06:00 [pubmed]
PHST- 2012/04/03 06:00 [medline]
AID - S0198-8859(11)00529-5 [pii]
AID - 10.1016/j.humimm.2011.09.002 [doi]
PST - ppublish
SO  - Hum Immunol. 2011 Dec;72(12):1198-203. doi: 10.1016/j.humimm.2011.09.002. Epub 
      2011 Sep 22.