PMID- 21965124
OWN - NLM
STAT- MEDLINE
DCOM- 20120618
LR  - 20211020
IS  - 1432-1971 (Electronic)
IS  - 0172-0643 (Linking)
VI  - 33
IP  - 2
DP  - 2012 Feb
TI  - Plasmin generation and fibrinolysis in pediatric patients undergoing 
      cardiopulmonary bypass surgery.
PG  - 280-5
LID - 10.1007/s00246-011-0122-6 [doi]
AB  - This prospective, single-centre cohort study aimed to evaluate plasmin generation 
      and fibrinolysis during and after cardiopulmonary bypass (CPB) surgery in a 
      cohort of children up to 6 years of age. Blood samples were drawn at eight time 
      points: after induction of anesthesia, before unfractionated heparin (UFH), after 
      UFH, after initiation of bypass, before protamine, after protamine, after chest 
      closure, and 6 h after chest closure. The study identified an increase in 
      fibrinolysis during CPB and particularly up to 6 h afterward in children. This 
      could be the mechanism for the significant bleeding events observed in this young 
      population after CPB. This study establishes the foundation for future studies in 
      this area, particularly those focusing on clinical outcomes after CPB surgery.
FAU - Ignjatovic, Vera
AU  - Ignjatovic V
AD  - Murdoch Childrens Research Institute, Parkville, Australia. verai@unimelb.edu.au
FAU - Chandramouli, Aparajith
AU  - Chandramouli A
FAU - Than, Jenny
AU  - Than J
FAU - Summerhayes, Robyn
AU  - Summerhayes R
FAU - Newall, Fiona
AU  - Newall F
FAU - Horton, Steve
AU  - Horton S
FAU - Cochrane, Andrew
AU  - Cochrane A
FAU - Monagle, Paul
AU  - Monagle P
LA  - eng
PT  - Journal Article
DEP - 20111002
PL  - United States
TA  - Pediatr Cardiol
JT  - Pediatric cardiology
JID - 8003849
RN  - 0 (Hemostatics)
RN  - 9087-70-1 (Aprotinin)
RN  - EC 3.4.21.7 (Fibrinolysin)
SB  - IM
MH  - Aprotinin/therapeutic use
MH  - Cardiopulmonary Bypass/*adverse effects
MH  - Child
MH  - Female
MH  - Fibrinolysin/*metabolism
MH  - *Fibrinolysis
MH  - Heart Defects, Congenital/*surgery
MH  - Hemorrhage/drug therapy/etiology/physiopathology
MH  - Hemostatics/therapeutic use
MH  - Humans
MH  - Male
MH  - Prospective Studies
EDAT- 2011/10/04 06:00
MHDA- 2012/06/19 06:00
CRDT- 2011/10/04 06:00
PHST- 2011/05/25 00:00 [received]
PHST- 2011/09/12 00:00 [accepted]
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/04 06:00 [pubmed]
PHST- 2012/06/19 06:00 [medline]
AID - 10.1007/s00246-011-0122-6 [doi]
PST - ppublish
SO  - Pediatr Cardiol. 2012 Feb;33(2):280-5. doi: 10.1007/s00246-011-0122-6. Epub 2011 
      Oct 2.