PMID- 21965637
OWN - NLM
STAT- MEDLINE
DCOM- 20120424
LR  - 20221207
IS  - 1499-2752 (Electronic)
IS  - 0315-162X (Linking)
VI  - 38
IP  - 12
DP  - 2011 Dec
TI  - The role of tumor necrosis factor-alpha promoter genetic variation in Takayasu 
      arteritis susceptibility and medical treatment.
PG  - 2602-7
LID - 10.3899/jrheum.110231 [doi]
AB  - OBJECTIVE: Tumor necrosis factor-alpha (TNF-alpha) is a multifunctional proinflammatory 
      cytokine that influences the pathogenesis of Takayasu arteritis (TA). There is 
      still no evidence of the relationship between TNF-alpha gene promoter polymorphisms 
      and TA. We examined whether variations in the TNF-alpha promoter region may lead to 
      TA susceptibility and disease progression. METHODS: Five TNF-alpha gene promoter 
      polymorphisms (-238G/A, -308G/A, -857C/T, -863C/A, and -1031C/T) were analyzed in 
      110 Chinese Han patients with TA, with a control group of 362 unrelated healthy 
      individuals. Genotypes of TNF-alpha gene promoter polymorphisms were identified by 
      direct sequencing. TNF-alpha plasma concentrations were determined by ELISA. RESULTS: 
      Our results indicated that the frequency of the -863A allele was significantly 
      lower in the patients with TA than in the controls (18.2% vs 25.7%; p = 0.011), 
      but the significance was lost after Bonferroni correction (p(c) = 0.055). The 
      frequency of -863CA/AA genotypes was significantly lower in the patients with 
      refractory TA than in those with the 863CC genotype (22.4% vs 44.2%; p(c) < 
      0.01). The frequency of the GGCCT haplotype was significantly higher in patients 
      than in the controls, while the frequencies of GGCAT and GGCCC haplotypes were 
      significantly lower in patients than in controls. The plasma TNF-alpha concentrations 
      were significantly lower in the subjects carrying the -863A allele than in those 
      without. Patients with active TA had a significant increase in plasma levels of 
      TNF-alpha compared with remission patients and the control group. CONCLUSION: 
      Polymorphisms of the TNF-alpha promoter are not associated with TA in the Chinese Han 
      population. The A allele of the -863C/A polymorphism is associated with decreased 
      TNF-alpha expression, which might affect medical treatment.
FAU - Lv, Naqiang
AU  - Lv N
AD  - Department of Cardiology, Fuwai Hospital and Cardiovascular Institute, Chinese 
      Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
FAU - Dang, Aimin
AU  - Dang A
FAU - Zhu, Xilin
AU  - Zhu X
FAU - Liu, Ying
AU  - Liu Y
FAU - Liu, Yiwen
AU  - Liu Y
FAU - Zheng, Deyu
AU  - Zheng D
FAU - Hui, Rutai
AU  - Hui R
FAU - Liu, Guozhang
AU  - Liu G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111001
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asian People/genetics
MH  - Child
MH  - Ethnicity/genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - *Promoter Regions, Genetic
MH  - Takayasu Arteritis/*genetics/*therapy
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - Young Adult
EDAT- 2011/10/04 06:00
MHDA- 2012/04/25 06:00
CRDT- 2011/10/04 06:00
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/04 06:00 [pubmed]
PHST- 2012/04/25 06:00 [medline]
AID - jrheum.110231 [pii]
AID - 10.3899/jrheum.110231 [doi]
PST - ppublish
SO  - J Rheumatol. 2011 Dec;38(12):2602-7. doi: 10.3899/jrheum.110231. Epub 2011 Oct 1.