PMID- 21966944
OWN - NLM
STAT- MEDLINE
DCOM- 20121004
LR  - 20120424
IS  - 1943-3670 (Electronic)
IS  - 0022-3492 (Linking)
VI  - 83
IP  - 5
DP  - 2012 May
TI  - Association of serum and crevicular visfatin levels in periodontal health and 
      disease with type 2 diabetes mellitus.
PG  - 629-34
LID - 10.1902/jop.2011.110272 [doi]
AB  - BACKGROUND: Levels of visfatin in serum and gingival crevicular fluid (GCF) were 
      explored in patients with periodontal health, periodontal disease with and 
      without type 2 diabetes mellitus (t2 DM) and were found to be elevated with 
      periodontal disease, and were correlated with periodontal clinical parameters. DM 
      and chronic periodontitis (CP) are associated with each other. Adipokines, 
      specifically visfatin, are secreted from adipocytes and are thought to cause 
      insulin resistance. The purpose of this study is to determine the presence of 
      visfatin in serum and GCF in t2 DM among individuals with CP and to find an 
      association, if any. METHODS: Thirty individuals (15 males and 15 females) were 
      selected based on their clinical parameters into three groups: group 1 (10 
      healthy), group 2 (10 well-controlled t2 DM among individuals with CP), and group 
      3 (10 individuals with CP and without diabetes). Serum and GCF samples were 
      collected to estimate the levels of visfatin using enzyme linked immunosorbent 
      assay. RESULTS: The mean visfatin concentration increased in both serum and GCF 
      in individuals with t2 DM with CP. Also, it was observed that visfatin in both 
      serum and GCF correlated positively with all the periodontal parameters. 
      CONCLUSIONS: All the samples in each group tested positive for visfatin assay. 
      Serum and GCF visfatin concentration in both t2 DM with CP and individuals with 
      CP and without diabetes correlated positively with all the clinical parameters. 
      Additional large-scale longitudinal studies should be performed to confirm 
      positive correlations.
FAU - Pradeep, A R
AU  - Pradeep AR
AD  - Department of Periodontics, Government Dental College and Research Institute, 
      Bangalore, India. periodontics_gdc@yahoo.co.in
FAU - Raghavendra, N M
AU  - Raghavendra NM
FAU - Sharma, Anuj
AU  - Sharma A
FAU - Patel, Swati Pradeep
AU  - Patel SP
FAU - Raju, Arjun
AU  - Raju A
FAU - Kathariya, Rahul
AU  - Kathariya R
FAU - Rao, Nishanth S
AU  - Rao NS
FAU - Naik, Savitha B
AU  - Naik SB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111003
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - EC 2.4.2.12 (Nicotinamide Phosphoribosyltransferase)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Chronic Periodontitis/blood/*complications/*enzymology
MH  - Diabetes Mellitus, Type 2/blood/*complications/*enzymology
MH  - Female
MH  - Gingival Crevicular Fluid/*enzymology
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Nicotinamide Phosphoribosyltransferase/blood/*metabolism
MH  - Statistics, Nonparametric
MH  - Young Adult
EDAT- 2011/10/05 06:00
MHDA- 2012/10/05 06:00
CRDT- 2011/10/05 06:00
PHST- 2011/10/05 06:00 [entrez]
PHST- 2011/10/05 06:00 [pubmed]
PHST- 2012/10/05 06:00 [medline]
AID - 10.1902/jop.2011.110272 [doi]
PST - ppublish
SO  - J Periodontol. 2012 May;83(5):629-34. doi: 10.1902/jop.2011.110272. Epub 2011 Oct 
      3.