PMID- 21967324
OWN - NLM
STAT- MEDLINE
DCOM- 20120607
LR  - 20151113
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 19
IP  - 3
DP  - 2012 Mar
TI  - Fatigue, depression, and health-related quality of life in patients with multiple 
      sclerosis in Isfahan, Iran.
PG  - 431-7
LID - 10.1111/j.1468-1331.2011.03535.x [doi]
AB  - BACKGROUND AND PURPOSE: Quality of life (QoL) of patients with multiple sclerosis 
      (MS) is worse than that of other chronic diseases. There is a need to examine the 
      impact of fatigue and depression on the QoL independent of level of physical 
      disability in MS. The aim of this study is to explore physical, psychological, 
      and social aspects of health-related QoL (HRQoL) of MS patients in association 
      with physical disability, fatigue, and depression. METHODS: In a cross-sectional 
      study, 281 (63.4% women, 36.6% men) patients with MS participated in the study. 
      The HRQoL was assessed by the Persian version of the multiple sclerosis quality 
      of life (MSQoL-54) questionnaires. Other covariates included in the study were 
      disease type, physical disability, fatigue, disease impact, and depression. 
      RESULTS: In univariate analysis disease type, physical disability, fatigue, 
      disease impact, and depression were significantly associated with both physical 
      and mental health composite summaries of MSQoL-54. In multivariate regression 
      analysis, patients' physical disability remained significantly associated with 
      both components of MSQoL-54, whilst fatigue and depression were associated with 
      physical and mental composite summaries, respectively. CONCLUSIONS: Our findings 
      suggest that MS-related physical disability, fatigue, and depression affect the 
      HRQoL of MS patients, independently of each other and other potential confounding 
      factors. Effective interventions that target fatigue and depression may help 
      improve the QoL of patients, regardless of their disease type and level of 
      disability.
CI  - (c) 2011 The Author(s). European Journal of Neurology (c) 2011 EFNS.
FAU - Kargarfard, M
AU  - Kargarfard M
AD  - Faculty of Physical Education and Sport Sciences, University of Isfahan, Isfahan, 
      Iran. m.hayatbakhsh@uq.edu.au
FAU - Eetemadifar, M
AU  - Eetemadifar M
FAU - Mehrabi, M
AU  - Mehrabi M
FAU - Maghzi, A H
AU  - Maghzi AH
FAU - Hayatbakhsh, M R
AU  - Hayatbakhsh MR
LA  - eng
PT  - Journal Article
DEP - 20111004
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Depression/*epidemiology/etiology
MH  - Fatigue/*epidemiology/etiology
MH  - Female
MH  - Humans
MH  - Iran/epidemiology
MH  - Male
MH  - Multiple Sclerosis/*complications/*psychology
MH  - *Quality of Life
EDAT- 2011/10/05 06:00
MHDA- 2012/06/08 06:00
CRDT- 2011/10/05 06:00
PHST- 2011/10/05 06:00 [entrez]
PHST- 2011/10/05 06:00 [pubmed]
PHST- 2012/06/08 06:00 [medline]
AID - 10.1111/j.1468-1331.2011.03535.x [doi]
PST - ppublish
SO  - Eur J Neurol. 2012 Mar;19(3):431-7. doi: 10.1111/j.1468-1331.2011.03535.x. Epub 
      2011 Oct 4.