PMID- 2196745
OWN - NLM
STAT- MEDLINE
DCOM- 19900821
LR  - 20190714
IS  - 0042-6822 (Print)
IS  - 0042-6822 (Linking)
VI  - 177
IP  - 2
DP  - 1990 Aug
TI  - Restricted expression of measles virus in primary rat astroglial cells.
PG  - 802-6
AB  - Persistent infection of the central nervous system (CNS) with measles virus (MV) 
      is associated with characteristic restrictions of viral envelope gene expression 
      as documented in subacute sclerosing panencephalitis (SSPE), measles inclusion 
      body encephalitis (MIBE), or subacute measles encephalitis (SAME) in rats. To 
      determine whether these restrictions are the result of a long lasting virus-host 
      cell interaction or primarily based on intrinsic brain cell factors MV gene 
      expression was analyzed in primary rat astroglial cultures. It could be shown 
      that MV infection of these cells led to a defective replication cycle with a 
      reduced synthesis of viral envelope proteins and a steep expression gradient of 
      the monocistronic viral mRNAs similar to the findings in brain tissue of SSPE, 
      MIBE, and SAME. This restriction of MV gene expression has not been observed in 
      cells of nonneural origin. We suggest that this cell-type specific regulation of 
      MV gene expression contributes to early events in the establishment of MV 
      persistent infection in CNS tissue.
FAU - Schneider-Schaulies, S
AU  - Schneider-Schaulies S
AD  - Institut fur Virologie und Immunbiologie, Universitat Wurzburg, Federal Republic 
      of Germany.
FAU - Liebert, U G
AU  - Liebert UG
FAU - Baczko, K
AU  - Baczko K
FAU - ter Meulen, V
AU  - ter Meulen V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (RNA, Messenger)
RN  - 0 (Viral Structural Proteins)
SB  - IM
MH  - Animals
MH  - Astrocytes/*microbiology
MH  - Blotting, Northern
MH  - *Cell Transformation, Viral
MH  - Cells, Cultured
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Fluorescent Antibody Technique
MH  - Gene Expression
MH  - Measles virus/*genetics
MH  - Molecular Weight
MH  - RNA, Messenger/analysis/genetics
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Vero Cells
MH  - Viral Structural Proteins/analysis/biosynthesis/*genetics
EDAT- 1990/08/01 00:00
MHDA- 1990/08/01 00:01
CRDT- 1990/08/01 00:00
PHST- 1990/08/01 00:00 [pubmed]
PHST- 1990/08/01 00:01 [medline]
PHST- 1990/08/01 00:00 [entrez]
AID - 10.1016/0042-6822(90)90553-4 [doi]
PST - ppublish
SO  - Virology. 1990 Aug;177(2):802-6. doi: 10.1016/0042-6822(90)90553-4.