PMID- 21967459
OWN - NLM
STAT- MEDLINE
DCOM- 20111122
LR  - 20191112
IS  - 2162-6537 (Electronic)
IS  - 0731-8898 (Linking)
VI  - 30
IP  - 2
DP  - 2011
TI  - Radioprotective role of selenium after single-dose radioiodine ((1)(3)(1)I) exposure to 
      red blood cells of rats.
PG  - 153-62
AB  - The present study elucidated the protective potential of selenium following 
      (1)(3)(1)I-induced alterations in rat blood. Forty rats were segregated into 4 groups. 
      Animals in Group I served as normal controls, Group II animals were injected with 
      a single dose of 3.7 Mbq of (1)(3)(1)I (carrier free), Group III animals were 
      supplemented with selenium (1 ppm), and Group IV animals were given a combined 
      treatment of selenium and (1)(3)(1)I. (1)(3)(1)I treatment of rats showed significant 
      increases in total leukocyte counts (TLCs), lymphocytes, and neutrophils 
      (monocytes and eosinophils were not recorded). These were significantly restored 
      upon supplementation of selenium. Lipid peroxidase (LPO), glutathione peroxidase 
      (GSH-PX), reduced glutathione (GSH), superoxide dismutase (SOD), and 
      delta-aminolevulinic acid dehydratase (delta-ALAD) were found to be enhanced following 
      (1)(3)(1)I treatment. However, the levels of catalase were found to be decreased. 
      Selenium administration to (1)(3)(1)I-treated rats resulted in significant restoration 
      of these enzyme activities. Scanning electron microscope (SEM) studies also 
      revealed various surface deformities in erythrocytes after (1)(3)(1)I treatment, which 
      upon supplementation with selenium were significantly restored. In conclusion, 
      selenium may prove to be an effective radioprotector following (1)(3)(1)I treatment.
FAU - Sood, Abhilasha
AU  - Sood A
AD  - Department of Biophysics, Panjab University, Chandigarh, India.
FAU - Chadha, Vijayta Dani
AU  - Chadha VD
FAU - Dhawan, Devinder K
AU  - Dhawan DK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Environ Pathol Toxicol Oncol
JT  - Journal of environmental pathology, toxicology and oncology : official organ of 
      the International Society for Environmental Toxicology and Cancer
JID - 8501420
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Radiation-Protective Agents)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 4.2.1.24 (Porphobilinogen Synthase)
RN  - GAN16C9B8O (Glutathione)
RN  - HIW548RQ3W (Sodium Selenite)
SB  - IM
MH  - Animals
MH  - Catalase/metabolism
MH  - Erythrocytes/*drug effects/metabolism/*radiation effects/ultrastructure
MH  - Female
MH  - Glutathione/metabolism
MH  - Iodine Radioisotopes/*adverse effects
MH  - Lipid Peroxidation/drug effects/radiation effects
MH  - Porphobilinogen Synthase/metabolism
MH  - Radiation-Protective Agents/administration & dosage/*therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sodium Selenite/administration & dosage/*therapeutic use
MH  - Superoxide Dismutase/metabolism
EDAT- 2011/10/05 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/05 06:00
PHST- 2011/10/05 06:00 [entrez]
PHST- 2011/10/05 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 76aa57c972132785,08eecbad61db2102 [pii]
AID - 10.1615/jenvironpatholtoxicoloncol.v30.i2.60 [doi]
PST - ppublish
SO  - J Environ Pathol Toxicol Oncol. 2011;30(2):153-62. doi: 
      10.1615/jenvironpatholtoxicoloncol.v30.i2.60.